TY - JOUR
T1 - The michael addition of sulfur anions to β,β-substituted Nα-formyl-α,β-dehydroamino acid esters
AU - Freeman Stanfield, C.
AU - Hruby, Victor J.
N1 - Funding Information:
Acknowledgment: This work was supported by the National Science
PY - 1988/4/1
Y1 - 1988/4/1
N2 - The addition of lithium benzylthiolates to Nα-formyl-α,β-dehydro-α-amino acid esters gave protected Nα-formyl-β-S-benzyl-β,S-dialkyl- cysteine esters. Hydrolysis and Nα-protection produced β,β-dialkyl-cysteines which can be used for peptide synthesis.
AB - The addition of lithium benzylthiolates to Nα-formyl-α,β-dehydro-α-amino acid esters gave protected Nα-formyl-β-S-benzyl-β,S-dialkyl- cysteine esters. Hydrolysis and Nα-protection produced β,β-dialkyl-cysteines which can be used for peptide synthesis.
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U2 - 10.1080/00397918808060748
DO - 10.1080/00397918808060748
M3 - Article
AN - SCOPUS:77954697400
SN - 0039-7911
VL - 18
SP - 531
EP - 543
JO - Synthetic Communications
JF - Synthetic Communications
IS - 5
ER -