TY - JOUR
T1 - The metabolic impact of small intestinal nutrient sensing
AU - Duca, Frank A.
AU - Waise, T. M.Zaved
AU - Peppler, Willem T.
AU - Lam, Tony K.T.
N1 - Funding Information:
F.A.D. is funded by the National Institutes of Health (NIH-1R01DK121804) and United States Department of Agriculture (USDA)–National Institute of Food and Agriculture (NIFA) (2019-67017-29252). T.M.Z.W. is supported by a Diabetes Canada post-doctoral fellowship. W.T.P. is supported by a Canadian Institutes of Health Research (CIHR) post-doctoral fellowship. T.K.T.L. laboratory is supported by a CIHR Foundation Grant (FDN-143204). T.K.T.L. holds the John Kitson McIvor (1915–1942) Endowed Chair in Diabetes Research & the Tier 1 Canada Research Chair in Diabetes and Obesity at the Toronto General Hospital Research Institute and the University of Toronto.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The gastrointestinal tract maintains energy and glucose homeostasis, in part through nutrient-sensing and subsequent signaling to the brain and other tissues. In this review, we highlight the role of small intestinal nutrient-sensing in metabolic homeostasis, and link high-fat feeding, obesity, and diabetes with perturbations in these gut-brain signaling pathways. We identify how lipids, carbohydrates, and proteins, initiate gut peptide release from the enteroendocrine cells through small intestinal sensing pathways, and how these peptides regulate food intake, glucose tolerance, and hepatic glucose production. Lastly, we highlight how the gut microbiota impact small intestinal nutrient-sensing in normal physiology, and in disease, pharmacological and surgical settings. Emerging evidence indicates that the molecular mechanisms of small intestinal nutrient sensing in metabolic homeostasis have physiological and pathological impact as well as therapeutic potential in obesity and diabetes.
AB - The gastrointestinal tract maintains energy and glucose homeostasis, in part through nutrient-sensing and subsequent signaling to the brain and other tissues. In this review, we highlight the role of small intestinal nutrient-sensing in metabolic homeostasis, and link high-fat feeding, obesity, and diabetes with perturbations in these gut-brain signaling pathways. We identify how lipids, carbohydrates, and proteins, initiate gut peptide release from the enteroendocrine cells through small intestinal sensing pathways, and how these peptides regulate food intake, glucose tolerance, and hepatic glucose production. Lastly, we highlight how the gut microbiota impact small intestinal nutrient-sensing in normal physiology, and in disease, pharmacological and surgical settings. Emerging evidence indicates that the molecular mechanisms of small intestinal nutrient sensing in metabolic homeostasis have physiological and pathological impact as well as therapeutic potential in obesity and diabetes.
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U2 - 10.1038/s41467-021-21235-y
DO - 10.1038/s41467-021-21235-y
M3 - Review article
C2 - 33568676
AN - SCOPUS:85101011633
SN - 2041-1723
VL - 12
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 903
ER -