The meddling microbes midst our medicines

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


It is not surprising that the complex metabolic machinery of the gut microbiome has accidental, or directed, ability to alter our medicines and influence their efficacy. What is not known is the extent to which this has contributed to drug failures or contraindications, or to the derailment of clinical trials. Some studies are unraveling the mechanisms by which the microbiota alter specific drugs, such as digoxin, and contribute to variations in efficacies between patient populations. Microbiome profiling, therefore, may well become an inevitable arm of all clinical trials in the future.

Original languageEnglish (US)
JournalGut microbes
Issue number5
StatePublished - Sep 2013


  • Digoxin
  • Eggerthella lenta
  • Medicines
  • Microbiota

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases


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