TY - JOUR
T1 - The mechanism of rapid, shallow breathing after inhaling histamine aerosol in exercising dogs
AU - Bleecker, E. R.
AU - Cotton, D. J.
AU - Fischer, S. P.
AU - Graf, P. D.
AU - Gold, W. M.
AU - Nadel, J. A.
PY - 1976
Y1 - 1976
N2 - In 4 unsedated, exercising dogs, we studied the effects of inhaled histamine aerosol on minute volume of ventilation, respiratory frequency, tidal volume, total pulmonary resistance, and dynamic pulmonary compliance. Inhalation (5 breaths) of 1 to 2 per cent histamine aerosols increased minute ventilation (mean, 50 per cent; P<0.001) by increasing respiratory frequency (mean, 166 per cent; P<0.001), despite decreasing tidal volume (mean, 42 per cent; P<0.0001). Total pulmonary resistance increased (mean, 200 per cent; P<0.001), and dynamic pulmonary compliance decreased (mean, 51 per cent; P<0.001). Breathing supplemental O 2 did not affect the ventilatory response to histamine. Adding external resistive loads to a dog's airway did not simulate the pattern of rapid, shallow breathing produced by histamine. Inhalation of terbutaline prevented the changes in total pulmonary resistance and dynamic pulmonary compliance but did not alter the ventilatory response to histamine. When conduction in the cervical vagus nerves (which were implanted chronically in skin loops) was blocked by cooling, the ventilatory response to histamine was abolished. It is concluded that histamine stimulates breathing by stimulation of receptors whose afferent pathways are in the vagus nerves; the effective stimulus is not bronchoconstriction but is presumably due to direct stimulation of airway receptors.
AB - In 4 unsedated, exercising dogs, we studied the effects of inhaled histamine aerosol on minute volume of ventilation, respiratory frequency, tidal volume, total pulmonary resistance, and dynamic pulmonary compliance. Inhalation (5 breaths) of 1 to 2 per cent histamine aerosols increased minute ventilation (mean, 50 per cent; P<0.001) by increasing respiratory frequency (mean, 166 per cent; P<0.001), despite decreasing tidal volume (mean, 42 per cent; P<0.0001). Total pulmonary resistance increased (mean, 200 per cent; P<0.001), and dynamic pulmonary compliance decreased (mean, 51 per cent; P<0.001). Breathing supplemental O 2 did not affect the ventilatory response to histamine. Adding external resistive loads to a dog's airway did not simulate the pattern of rapid, shallow breathing produced by histamine. Inhalation of terbutaline prevented the changes in total pulmonary resistance and dynamic pulmonary compliance but did not alter the ventilatory response to histamine. When conduction in the cervical vagus nerves (which were implanted chronically in skin loops) was blocked by cooling, the ventilatory response to histamine was abolished. It is concluded that histamine stimulates breathing by stimulation of receptors whose afferent pathways are in the vagus nerves; the effective stimulus is not bronchoconstriction but is presumably due to direct stimulation of airway receptors.
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M3 - Article
C2 - 984583
AN - SCOPUS:0017147787
SN - 0003-0805
VL - 114
SP - 909
EP - 916
JO - American Review of Respiratory Disease
JF - American Review of Respiratory Disease
IS - 5
ER -