The mechanism of non-homologous end-joining: A synopsis of synapsis

Eric Weterings; Dik C. Van Gent

doi:10.1016/j.dnarep.2004.06.003

The mechanism of non-homologous end-joining: A synopsis of synapsis

Eric Weterings, Dik C. Van Gent

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

173 Scopus citations

Abstract

Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway. We are now entering the phase in which we begin to understand basic concepts of the reaction mechanism and regulation of non-homologous end-joining. This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends.

Original language	English (US)
Pages (from-to)	1425-1435
Number of pages	11
Journal	DNA Repair
Volume	3
Issue number	11
DOIs	https://doi.org/10.1016/j.dnarep.2004.06.003
State	Published - Nov 2 2004

Keywords

DNA double-strand-breaks
Non-homologous end-joining

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.dnarep.2004.06.003

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title = "The mechanism of non-homologous end-joining: A synopsis of synapsis",

abstract = "Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway. We are now entering the phase in which we begin to understand basic concepts of the reaction mechanism and regulation of non-homologous end-joining. This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends.",

keywords = "DNA double-strand-breaks, Non-homologous end-joining",

author = "Eric Weterings and {Van Gent}, {Dik C.}",

note = "Funding Information: The authors would like to thank Drs. Bobby Florea, Mauro Modesti, Roland Kanaar, Koos Jaspers and Piet Weterings for critical reading of the manuscript. Due to the large number of publications on the subject of end-joining, we frequently refer to reviews instead of original publications. We apologize to all colleagues whose work was not included in our review. This work was supported by grants from the Dutch Scientific Organization (NWO, CW98302) and from the European Union (NB04.14-14). ",

year = "2004",

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doi = "10.1016/j.dnarep.2004.06.003",

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T2 - A synopsis of synapsis

AU - Weterings, Eric

AU - Van Gent, Dik C.

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PY - 2004/11/2

Y1 - 2004/11/2

N2 - Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway. We are now entering the phase in which we begin to understand basic concepts of the reaction mechanism and regulation of non-homologous end-joining. This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends.

AB - Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway. We are now entering the phase in which we begin to understand basic concepts of the reaction mechanism and regulation of non-homologous end-joining. This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends.

KW - DNA double-strand-breaks

KW - Non-homologous end-joining

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The mechanism of non-homologous end-joining: A synopsis of synapsis

Abstract

Keywords

ASJC Scopus subject areas

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