This review summarizes the key roles played by the enzyme CoA-IT in inflammatory cells: orchestrating the movement of arachidonate between phospholipid pools; maintenance of arachidonate levels within specific phospolipid pools; regulation of arachidonate movement during stimulation; generation of lyso PAF for PAF biosynthesis; providing arachidonate-containing substrates to PLA2 for arachidonic acid release and eicosanoid generation; and maintenance of cells in a proliferative state.
|Original language||English (US)|
|Number of pages||9|
|Journal||Pharmacology Reviews and Communications|
|State||Published - 1996|
- Platelet-activating factor
ASJC Scopus subject areas