The key roles played by CoA-independent transacylase in arachidonate movement and inflammatory cell functions

James D. Winkler; Marc E. Surette; Alfred N. Fonteh; Floyd H. Chilton

The key roles played by CoA-independent transacylase in arachidonate movement and inflammatory cell functions

James D. Winkler, Marc E. Surette, Alfred N. Fonteh, Floyd H. Chilton

Research output: Contribution to journal › Review article › peer-review

Abstract

This review summarizes the key roles played by the enzyme CoA-IT in inflammatory cells: orchestrating the movement of arachidonate between phospholipid pools; maintenance of arachidonate levels within specific phospolipid pools; regulation of arachidonate movement during stimulation; generation of lyso PAF for PAF biosynthesis; providing arachidonate-containing substrates to PLA₂ for arachidonic acid release and eicosanoid generation; and maintenance of cells in a proliferative state.

Original language	English (US)
Pages (from-to)	19-27
Number of pages	9
Journal	Pharmacology Reviews and Communications
Volume	8
Issue number	1
State	Published - 1996
Externally published	Yes

Keywords

Arachidonate
Eicosanoids
Phospholipase
Platelet-activating factor
Transacylase

ASJC Scopus subject areas

Pharmacology

Cite this

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title = "The key roles played by CoA-independent transacylase in arachidonate movement and inflammatory cell functions",

abstract = "This review summarizes the key roles played by the enzyme CoA-IT in inflammatory cells: orchestrating the movement of arachidonate between phospholipid pools; maintenance of arachidonate levels within specific phospolipid pools; regulation of arachidonate movement during stimulation; generation of lyso PAF for PAF biosynthesis; providing arachidonate-containing substrates to PLA2 for arachidonic acid release and eicosanoid generation; and maintenance of cells in a proliferative state.",

keywords = "Arachidonate, Eicosanoids, Phospholipase, Platelet-activating factor, Transacylase",

author = "Winkler, {James D.} and Surette, {Marc E.} and Fonteh, {Alfred N.} and Chilton, {Floyd H.}",

year = "1996",

language = "English (US)",

volume = "8",

pages = "19--27",

journal = "Pharmacology Reviews and Communications",

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T1 - The key roles played by CoA-independent transacylase in arachidonate movement and inflammatory cell functions

AU - Winkler, James D.

AU - Surette, Marc E.

AU - Fonteh, Alfred N.

AU - Chilton, Floyd H.

PY - 1996

Y1 - 1996

N2 - This review summarizes the key roles played by the enzyme CoA-IT in inflammatory cells: orchestrating the movement of arachidonate between phospholipid pools; maintenance of arachidonate levels within specific phospolipid pools; regulation of arachidonate movement during stimulation; generation of lyso PAF for PAF biosynthesis; providing arachidonate-containing substrates to PLA2 for arachidonic acid release and eicosanoid generation; and maintenance of cells in a proliferative state.

AB - This review summarizes the key roles played by the enzyme CoA-IT in inflammatory cells: orchestrating the movement of arachidonate between phospholipid pools; maintenance of arachidonate levels within specific phospolipid pools; regulation of arachidonate movement during stimulation; generation of lyso PAF for PAF biosynthesis; providing arachidonate-containing substrates to PLA2 for arachidonic acid release and eicosanoid generation; and maintenance of cells in a proliferative state.

KW - Arachidonate

KW - Eicosanoids

KW - Phospholipase

KW - Platelet-activating factor

KW - Transacylase

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AN - SCOPUS:2842562696

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JF - Pharmacology Reviews and Communications

IS - 1

ER -

The key roles played by CoA-independent transacylase in arachidonate movement and inflammatory cell functions

Abstract

Keywords

ASJC Scopus subject areas

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