The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases

Simon J. Conway; Thomas Doetschman; Mohamad Azhar

doi:10.1100/tsw.2011.132

The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases

Simon J. Conway, Thomas Doetschman, Mohamad Azhar

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.

Original language	English (US)
Pages (from-to)	1509-1524
Number of pages	16
Journal	TheScientificWorldJournal
Volume	11
DOIs	https://doi.org/10.1100/tsw.2011.132
State	Published - Jul 28 2011
Externally published	Yes

Keywords

BMP
Bone morphogenetic protein
Heart development
Heart valves
Marfan syndrome
Periostin
TGFβ
Transforming growth factor beta

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Environmental Science

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10.1100/tsw.2011.132

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title = "The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases",

abstract = "Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.",

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AU - Conway, Simon J.

AU - Doetschman, Thomas

AU - Azhar, Mohamad

PY - 2011/7/28

Y1 - 2011/7/28

N2 - Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.

AB - Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.

KW - BMP

KW - Bone morphogenetic protein

KW - Heart development

KW - Heart valves

KW - Marfan syndrome

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KW - TGFβ

KW - Transforming growth factor beta

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The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases

Abstract

Keywords

ASJC Scopus subject areas

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