The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity

Toru Uchimura; Yoshitaka Oyama; Meng Deng; Haitao Guo; Justin E. Wilson; Elena Rampanelli; Kevin D. Cook; Ichiro Misumi; Xianming Tan; Liang Chen; Brandon Johnson; Jason Tam; Wei Chun Chou; W. June Brickey; Alex Petrucelli; Jason K. Whitmire; Jenny P.Y. Ting

doi:10.1016/j.immuni.2018.10.008

The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity

Toru Uchimura
, Yoshitaka Oyama
, Meng Deng
, Haitao Guo
, Justin E. Wilson
, Elena Rampanelli
, Kevin D. Cook
, Ichiro Misumi
, Xianming Tan
, Liang Chen
, Brandon Johnson
, Jason Tam
, Wei Chun Chou
, W. June Brickey
, Alex Petrucelli
, Jason K. Whitmire
, Jenny P.Y. Ting

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

NLRC3 limits inflammatory signaling in myeloid cells, but its role in T cells has been unclear. Uchimura et al. reveal that T cell expression of Nlrc3 restricts autoimmune and virus-specific CD4 ⁺ T cell responses by attenuating T cell signaling and metabolic pathways in CD4 ⁺ T cells.

Original language	English (US)
Pages (from-to)	1049-1061.e6
Journal	Immunity
Volume	49
Issue number	6
DOIs	https://doi.org/10.1016/j.immuni.2018.10.008
State	Published - Dec 18 2018
Externally published	Yes

Keywords

CD4 T cell response
EAE
LCMV infection
NLRC3
NOD-like receptors
T cell receptor signaling
autoimmunity
inflammatory pathways

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2018.10.008

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Uchimura, T., Oyama, Y., Deng, M., Guo, H., Wilson, J. E., Rampanelli, E., Cook, K. D., Misumi, I., Tan, X., Chen, L., Johnson, B., Tam, J., Chou, W. C., Brickey, W. J., Petrucelli, A., Whitmire, J. K., & Ting, J. P. Y. (2018). The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity. Immunity, 49(6), 1049-1061.e6. https://doi.org/10.1016/j.immuni.2018.10.008

Uchimura, T, Oyama, Y, Deng, M, Guo, H, Wilson, JE, Rampanelli, E, Cook, KD, Misumi, I, Tan, X, Chen, L, Johnson, B, Tam, J, Chou, WC, Brickey, WJ, Petrucelli, A, Whitmire, JK & Ting, JPY 2018, 'The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity', Immunity, vol. 49, no. 6, pp. 1049-1061.e6. https://doi.org/10.1016/j.immuni.2018.10.008

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abstract = " NLRC3 limits inflammatory signaling in myeloid cells, but its role in T cells has been unclear. Uchimura et al. reveal that T cell expression of Nlrc3 restricts autoimmune and virus-specific CD4 + T cell responses by attenuating T cell signaling and metabolic pathways in CD4 + T cells.",

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KW - CD4 T cell response

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KW - LCMV infection

KW - NLRC3

KW - NOD-like receptors

KW - T cell receptor signaling

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The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity

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Keywords

ASJC Scopus subject areas

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