Abstract
NLRC3 limits inflammatory signaling in myeloid cells, but its role in T cells has been unclear. Uchimura et al. reveal that T cell expression of Nlrc3 restricts autoimmune and virus-specific CD4 + T cell responses by attenuating T cell signaling and metabolic pathways in CD4 + T cells.
Original language | English (US) |
---|---|
Pages (from-to) | 1049-1061.e6 |
Journal | Immunity |
Volume | 49 |
Issue number | 6 |
DOIs | |
State | Published - Dec 18 2018 |
Externally published | Yes |
Keywords
- CD4 T cell response
- EAE
- LCMV infection
- NLRC3
- NOD-like receptors
- T cell receptor signaling
- autoimmunity
- inflammatory pathways
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases