The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity

Toru Uchimura, Yoshitaka Oyama, Meng Deng, Haitao Guo, Justin E. Wilson, Elena Rampanelli, Kevin D. Cook, Ichiro Misumi, Xianming Tan, Liang Chen, Brandon Johnson, Jason Tam, Wei Chun Chou, W. June Brickey, Alex Petrucelli, Jason K. Whitmire, Jenny P.Y. Ting

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

NLRC3 limits inflammatory signaling in myeloid cells, but its role in T cells has been unclear. Uchimura et al. reveal that T cell expression of Nlrc3 restricts autoimmune and virus-specific CD4 + T cell responses by attenuating T cell signaling and metabolic pathways in CD4 + T cells.

Original languageEnglish (US)
Pages (from-to)1049-1061.e6
JournalImmunity
Volume49
Issue number6
DOIs
StatePublished - Dec 18 2018
Externally publishedYes

Keywords

  • autoimmunity
  • CD4 T cell response
  • EAE
  • inflammatory pathways
  • LCMV infection
  • NLRC3
  • NOD-like receptors
  • T cell receptor signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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