Abstract
Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.
Original language | English (US) |
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Pages (from-to) | 482-485 |
Number of pages | 4 |
Journal | Immunobiology |
Volume | 219 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2014 |
Keywords
- Aging
- Immunity
- MCMV
- Mice
- OT-1
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Hematology