The influence of intrinsic and extrinsic factors on immune system aging

Michael Badowski, Christopher L. Shultz, Yvette Eason, Nafees Ahmad, David T. Harris

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.

Original languageEnglish (US)
Pages (from-to)482-485
Number of pages4
Issue number6
StatePublished - Jun 2014


  • Aging
  • Immunity
  • MCMV
  • Mice
  • OT-1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology


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