The influence of intrinsic and extrinsic factors on immune system aging

Michael Badowski; Christopher L. Shultz; Yvette Eason; Nafees Ahmad; David T. Harris

doi:10.1016/j.imbio.2014.02.008

The influence of intrinsic and extrinsic factors on immune system aging

Michael Badowski, Christopher L. Shultz, Yvette Eason, Nafees Ahmad, David T. Harris

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8⁺28⁺ cells and an accumulation of KLRG1⁺ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8⁺28^- and KLRG1⁺ T cells with time. CD4⁺ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.

Original language	English (US)
Pages (from-to)	482-485
Number of pages	4
Journal	Immunobiology
Volume	219
Issue number	6
DOIs	https://doi.org/10.1016/j.imbio.2014.02.008
State	Published - Jun 2014

Keywords

Aging
Immunity
MCMV
Mice
OT-1

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Hematology

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10.1016/j.imbio.2014.02.008

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title = "The influence of intrinsic and extrinsic factors on immune system aging",

abstract = "Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.",

keywords = "Aging, Immunity, MCMV, Mice, OT-1",

author = "Michael Badowski and Shultz, {Christopher L.} and Yvette Eason and Nafees Ahmad and Harris, {David T.}",

note = "Funding Information: This work was supported in part by Grant #5 R01 AG038021-03 from the National Institute of Aging, National Institutes of Health .",

year = "2014",

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doi = "10.1016/j.imbio.2014.02.008",

language = "English (US)",

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AU - Badowski, Michael

AU - Shultz, Christopher L.

AU - Eason, Yvette

AU - Ahmad, Nafees

AU - Harris, David T.

N1 - Funding Information: This work was supported in part by Grant #5 R01 AG038021-03 from the National Institute of Aging, National Institutes of Health .

PY - 2014/6

Y1 - 2014/6

N2 - Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.

AB - Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.

KW - Aging

KW - Immunity

KW - MCMV

KW - Mice

KW - OT-1

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The influence of intrinsic and extrinsic factors on immune system aging

Abstract

Keywords

ASJC Scopus subject areas

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