The importance of mediation in reproductive health studies

Leslie V. Farland, Katharine F.B. Correia, Laura E. Dodge, Anna M. Modest, Paige L. Williams, Louisa H. Smith, Thomas L. Toth, Michele R. Hacker, Stacey A. Missmer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A mediator is a factor that occurs after the exposure of interest, precedes the outcome of interest (i.e. between the exposure and the outcome) and is associated with both the exposure and the outcome of interest (i.e. is on the pathway between exposure and outcome). Mediation analyses can be valuable in many reproductive health contexts, as mediation analysis can help researchers to better identify, quantify and understand the underlying pathways of the association they are studying. The purpose of this commentary is to introduce the concept of mediation and provide examples that solidify understanding of mediation for valid discovery and interpretation in the field of reproductive medicine.

Original languageEnglish (US)
Pages (from-to)1262-1266
Number of pages5
JournalHuman Reproduction
Issue number6
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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