The impact of some parameters on linkage analysis of Alzheimer's disease

J. F. Xu, E. W. Taylor, F. W. Lung, A. S. Chung, G. A. Chase, N. E. Maestri, D. A. Meyers

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The two‐point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age‐dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage. However, it is clear that, in some cases, it may lead to false positive evidence of linkage. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)407-412
Number of pages6
JournalGenetic Epidemiology
Issue number6
StatePublished - 1993
Externally publishedYes


  • disease gene frequency
  • familial Alzheimer's disease
  • genetic heterogeneity
  • genetic linkage analysis
  • incomplete penetrance rate
  • marker allele frequency
  • phenocopy rate

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)


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