TY - JOUR
T1 - The impact of physical activity on fatigue and quality of life in lung cancer patients
T2 - A randomised controlled trial protocol
AU - Dhillon, Haryana M.
AU - van der Ploeg, Hidde P.
AU - Bell, Melanie L.
AU - Boyer, Michael
AU - Clarke, Stephen
AU - Vardy, Janette
N1 - Funding Information:
The study has received funding from the Lance Armstrong Foundation / National Lung Cancer Alliance Partnership. A/Prof. Janette Vardy is funded by the Cancer Institute NSW and Dr Haryana Dhillon received funding from the Australasian Lung Trials Group and Psycho-Oncology Co-Operative Research Group (PoCoG). Dr Hidde van der Ploeg was supported by an Australian National Health and Medical Research Council programme grant (#301200). An equipment grant was received from the Sydney Cancer Centre Foundation for purchase of gymnasium equipment for use by trial participants.
PY - 2012/12/5
Y1 - 2012/12/5
N2 - Background: People with lung cancer have substantial symptom burden and more unmet needs than the general cancer population. Physical activity (PA) has been shown to positively influence quality of life (QOL), fatigue and daily functioning in the curative treatment of people with breast and colorectal cancers and lung diseases, as well as in palliative settings. A randomised controlled trial (RCT) is needed to determine if lung cancer patients benefit from structured PA intervention. The Physical Activity in Lung Cancer (PAL) trial is designed to evaluate the impact of a 2-month PA intervention on fatigue and QOL in patients with non-resectable lung cancer. Biological mechanisms will also be studied.Methods/design: A multi-centre RCT with patients randomised to usual care or a 2-month PA programme, involving supervised PA sessions including a behavioural change component and home-based PA. QOL questionnaires, disease and functional status and body composition will be assessed at baseline, 2, 4 and 6 months follow-up. The primary endpoint is comparative levels of fatigue between the 2 arms. Secondary endpoints include: QOL, functional abilities and physical function. Exploratory endpoints include: anxiety, depression, distress, dyspnoea, PA behaviour, fitness, hospitalisations, survival, cytokines and insulin-like growth factor levels.Discussion: This study will provide high-level evidence of the effect of PA programmes on cancer-related fatigue and QOL in patients with advanced lung cancer. If positive, the study has the potential to change care for people with cancer using a simple, inexpensive intervention to improve their QOL and help them maintain independent function for as long as possible.Trial registration: Australian New Zealand Clinical Trials Registry No. ACTRN12609000971235.
AB - Background: People with lung cancer have substantial symptom burden and more unmet needs than the general cancer population. Physical activity (PA) has been shown to positively influence quality of life (QOL), fatigue and daily functioning in the curative treatment of people with breast and colorectal cancers and lung diseases, as well as in palliative settings. A randomised controlled trial (RCT) is needed to determine if lung cancer patients benefit from structured PA intervention. The Physical Activity in Lung Cancer (PAL) trial is designed to evaluate the impact of a 2-month PA intervention on fatigue and QOL in patients with non-resectable lung cancer. Biological mechanisms will also be studied.Methods/design: A multi-centre RCT with patients randomised to usual care or a 2-month PA programme, involving supervised PA sessions including a behavioural change component and home-based PA. QOL questionnaires, disease and functional status and body composition will be assessed at baseline, 2, 4 and 6 months follow-up. The primary endpoint is comparative levels of fatigue between the 2 arms. Secondary endpoints include: QOL, functional abilities and physical function. Exploratory endpoints include: anxiety, depression, distress, dyspnoea, PA behaviour, fitness, hospitalisations, survival, cytokines and insulin-like growth factor levels.Discussion: This study will provide high-level evidence of the effect of PA programmes on cancer-related fatigue and QOL in patients with advanced lung cancer. If positive, the study has the potential to change care for people with cancer using a simple, inexpensive intervention to improve their QOL and help them maintain independent function for as long as possible.Trial registration: Australian New Zealand Clinical Trials Registry No. ACTRN12609000971235.
KW - Exercise
KW - Fatigue
KW - Lung cancer
KW - Physical activity
KW - Quality of life
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U2 - 10.1186/1471-2407-12-572
DO - 10.1186/1471-2407-12-572
M3 - Article
C2 - 23216897
AN - SCOPUS:84870352911
SN - 1471-2407
VL - 12
JO - BMC Cancer
JF - BMC Cancer
M1 - 572
ER -