The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy

Prerna Sharma; Kajal Shah; Johanna Loomba; Arti Patel; Indika Mallawaarachchi; Olivia Blazek; Sarah Ratcliffe; Khadijah Breathett; Amber E. Johnson; Angela M. Taylor; Michael Salerno; Michael Ragosta; Nishtha Sodhi; Daniel Addison; Selma Mohammed; Kenneth C. Bilchick; Sula Mazimba

doi:10.1002/clc.23908

The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy

Prerna Sharma, Kajal Shah, Johanna Loomba, Arti Patel, Indika Mallawaarachchi, Olivia Blazek, Sarah Ratcliffe, Khadijah Breathett, Amber E. Johnson, Angela M. Taylor, Michael Salerno, Michael Ragosta, Nishtha Sodhi, Daniel Addison, Selma Mohammed, Kenneth C. Bilchick, Sula Mazimba

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: The implications of coronavirus disease 2019 (COVID-19) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied. Hypothesis: To assess the outcomes of COVID-19 patients presenting with AMI undergoing an early invasive treatment strategy. Methods: This study was a cross-sectional, retrospective analysis of the National COVID Cohort Collaborative database including all patients presenting with a recorded diagnosis of AMI (ST-elevation myocardial infarction (MI) and non-ST elevation MI). COVID-19 positive patients with AMI were stratified into one of four groups: (1a) patients who had a coronary angiogram with percutaneous coronary intervention (PCI) within 3 days of their AMI; (1b) PCI within 3 days of AMI with coronary artery bypass graft (CABG) within 30 days; (2a) coronary angiogram without PCI and without CABG within 30 days; and (2b) coronary angiogram with CABG within 30 days. The main outcomes were respiratory failure, cardiogenic shock, prolonged length of stay, rehospitalization, and death. Results: There were 10 506 COVID-19 positive patients with a diagnosis of AMI. COVID-19 positive patients with PCI had 8.2 times higher odds of respiratory failure than COVID-19 negative patients (p =.001). The odds of prolonged length of stay were 1.7 times higher in COVID-19 patients who underwent PCI (p =.024) and 1.9 times higher in patients who underwent coronary angiogram followed by CABG (p =.001). Conclusion: These data demonstrate that COVID-19 positive patients with AMI undergoing early invasive coronary angiography had worse outcomes than COVID-19 negative patients.

Original language	English (US)
Pages (from-to)	1070-1078
Number of pages	9
Journal	Clinical cardiology
Volume	45
Issue number	10
DOIs	https://doi.org/10.1002/clc.23908
State	Published - Oct 2022
Externally published	Yes

Keywords

COVID-19
cardiac catheterization
pediatric clinical cardiology
percutaneous coronary intervention

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1002/clc.23908

Cite this

Sharma, P., Shah, K., Loomba, J., Patel, A., Mallawaarachchi, I., Blazek, O., Ratcliffe, S., Breathett, K., Johnson, A. E., Taylor, A. M., Salerno, M., Ragosta, M., Sodhi, N., Addison, D., Mohammed, S., Bilchick, K. C., & Mazimba, S. (2022). The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy. Clinical cardiology, 45(10), 1070-1078. https://doi.org/10.1002/clc.23908

Sharma, P, Shah, K, Loomba, J, Patel, A, Mallawaarachchi, I, Blazek, O, Ratcliffe, S, Breathett, K, Johnson, AE, Taylor, AM, Salerno, M, Ragosta, M, Sodhi, N, Addison, D, Mohammed, S, Bilchick, KC & Mazimba, S 2022, 'The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy', Clinical cardiology, vol. 45, no. 10, pp. 1070-1078. https://doi.org/10.1002/clc.23908

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title = "The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy",

abstract = "Background: The implications of coronavirus disease 2019 (COVID-19) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied. Hypothesis: To assess the outcomes of COVID-19 patients presenting with AMI undergoing an early invasive treatment strategy. Methods: This study was a cross-sectional, retrospective analysis of the National COVID Cohort Collaborative database including all patients presenting with a recorded diagnosis of AMI (ST-elevation myocardial infarction (MI) and non-ST elevation MI). COVID-19 positive patients with AMI were stratified into one of four groups: (1a) patients who had a coronary angiogram with percutaneous coronary intervention (PCI) within 3 days of their AMI; (1b) PCI within 3 days of AMI with coronary artery bypass graft (CABG) within 30 days; (2a) coronary angiogram without PCI and without CABG within 30 days; and (2b) coronary angiogram with CABG within 30 days. The main outcomes were respiratory failure, cardiogenic shock, prolonged length of stay, rehospitalization, and death. Results: There were 10 506 COVID-19 positive patients with a diagnosis of AMI. COVID-19 positive patients with PCI had 8.2 times higher odds of respiratory failure than COVID-19 negative patients (p =.001). The odds of prolonged length of stay were 1.7 times higher in COVID-19 patients who underwent PCI (p =.024) and 1.9 times higher in patients who underwent coronary angiogram followed by CABG (p =.001). Conclusion: These data demonstrate that COVID-19 positive patients with AMI undergoing early invasive coronary angiography had worse outcomes than COVID-19 negative patients.",

keywords = "COVID-19, cardiac catheterization, pediatric clinical cardiology, percutaneous coronary intervention",

author = "Prerna Sharma and Kajal Shah and Johanna Loomba and Arti Patel and Indika Mallawaarachchi and Olivia Blazek and Sarah Ratcliffe and Khadijah Breathett and Johnson, {Amber E.} and Taylor, {Angela M.} and Michael Salerno and Michael Ragosta and Nishtha Sodhi and Daniel Addison and Selma Mohammed and Bilchick, {Kenneth C.} and Sula Mazimba",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.",

year = "2022",

month = oct,

doi = "10.1002/clc.23908",

language = "English (US)",

volume = "45",

pages = "1070--1078",

journal = "Clinical cardiology",

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T1 - The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy

AU - Sharma, Prerna

AU - Shah, Kajal

AU - Loomba, Johanna

AU - Patel, Arti

AU - Mallawaarachchi, Indika

AU - Blazek, Olivia

AU - Ratcliffe, Sarah

AU - Breathett, Khadijah

AU - Johnson, Amber E.

AU - Taylor, Angela M.

AU - Salerno, Michael

AU - Ragosta, Michael

AU - Sodhi, Nishtha

AU - Addison, Daniel

AU - Mohammed, Selma

AU - Bilchick, Kenneth C.

AU - Mazimba, Sula

PY - 2022/10

Y1 - 2022/10

N2 - Background: The implications of coronavirus disease 2019 (COVID-19) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied. Hypothesis: To assess the outcomes of COVID-19 patients presenting with AMI undergoing an early invasive treatment strategy. Methods: This study was a cross-sectional, retrospective analysis of the National COVID Cohort Collaborative database including all patients presenting with a recorded diagnosis of AMI (ST-elevation myocardial infarction (MI) and non-ST elevation MI). COVID-19 positive patients with AMI were stratified into one of four groups: (1a) patients who had a coronary angiogram with percutaneous coronary intervention (PCI) within 3 days of their AMI; (1b) PCI within 3 days of AMI with coronary artery bypass graft (CABG) within 30 days; (2a) coronary angiogram without PCI and without CABG within 30 days; and (2b) coronary angiogram with CABG within 30 days. The main outcomes were respiratory failure, cardiogenic shock, prolonged length of stay, rehospitalization, and death. Results: There were 10 506 COVID-19 positive patients with a diagnosis of AMI. COVID-19 positive patients with PCI had 8.2 times higher odds of respiratory failure than COVID-19 negative patients (p =.001). The odds of prolonged length of stay were 1.7 times higher in COVID-19 patients who underwent PCI (p =.024) and 1.9 times higher in patients who underwent coronary angiogram followed by CABG (p =.001). Conclusion: These data demonstrate that COVID-19 positive patients with AMI undergoing early invasive coronary angiography had worse outcomes than COVID-19 negative patients.

AB - Background: The implications of coronavirus disease 2019 (COVID-19) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied. Hypothesis: To assess the outcomes of COVID-19 patients presenting with AMI undergoing an early invasive treatment strategy. Methods: This study was a cross-sectional, retrospective analysis of the National COVID Cohort Collaborative database including all patients presenting with a recorded diagnosis of AMI (ST-elevation myocardial infarction (MI) and non-ST elevation MI). COVID-19 positive patients with AMI were stratified into one of four groups: (1a) patients who had a coronary angiogram with percutaneous coronary intervention (PCI) within 3 days of their AMI; (1b) PCI within 3 days of AMI with coronary artery bypass graft (CABG) within 30 days; (2a) coronary angiogram without PCI and without CABG within 30 days; and (2b) coronary angiogram with CABG within 30 days. The main outcomes were respiratory failure, cardiogenic shock, prolonged length of stay, rehospitalization, and death. Results: There were 10 506 COVID-19 positive patients with a diagnosis of AMI. COVID-19 positive patients with PCI had 8.2 times higher odds of respiratory failure than COVID-19 negative patients (p =.001). The odds of prolonged length of stay were 1.7 times higher in COVID-19 patients who underwent PCI (p =.024) and 1.9 times higher in patients who underwent coronary angiogram followed by CABG (p =.001). Conclusion: These data demonstrate that COVID-19 positive patients with AMI undergoing early invasive coronary angiography had worse outcomes than COVID-19 negative patients.

KW - COVID-19

KW - cardiac catheterization

KW - pediatric clinical cardiology

KW - percutaneous coronary intervention

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The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy

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