The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy

Prerna Sharma, Kajal Shah, Johanna Loomba, Arti Patel, Indika Mallawaarachchi, Olivia Blazek, Sarah Ratcliffe, Khadijah Breathett, Amber E. Johnson, Angela M. Taylor, Michael Salerno, Michael Ragosta, Nishtha Sodhi, Daniel Addison, Selma Mohammed, Kenneth C. Bilchick, Sula Mazimba

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: The implications of coronavirus disease 2019 (COVID-19) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied. Hypothesis: To assess the outcomes of COVID-19 patients presenting with AMI undergoing an early invasive treatment strategy. Methods: This study was a cross-sectional, retrospective analysis of the National COVID Cohort Collaborative database including all patients presenting with a recorded diagnosis of AMI (ST-elevation myocardial infarction (MI) and non-ST elevation MI). COVID-19 positive patients with AMI were stratified into one of four groups: (1a) patients who had a coronary angiogram with percutaneous coronary intervention (PCI) within 3 days of their AMI; (1b) PCI within 3 days of AMI with coronary artery bypass graft (CABG) within 30 days; (2a) coronary angiogram without PCI and without CABG within 30 days; and (2b) coronary angiogram with CABG within 30 days. The main outcomes were respiratory failure, cardiogenic shock, prolonged length of stay, rehospitalization, and death. Results: There were 10 506 COVID-19 positive patients with a diagnosis of AMI. COVID-19 positive patients with PCI had 8.2 times higher odds of respiratory failure than COVID-19 negative patients (p =.001). The odds of prolonged length of stay were 1.7 times higher in COVID-19 patients who underwent PCI (p =.024) and 1.9 times higher in patients who underwent coronary angiogram followed by CABG (p =.001). Conclusion: These data demonstrate that COVID-19 positive patients with AMI undergoing early invasive coronary angiography had worse outcomes than COVID-19 negative patients.

Original languageEnglish (US)
Pages (from-to)1070-1078
Number of pages9
JournalClinical cardiology
Issue number10
StatePublished - Oct 2022
Externally publishedYes


  • COVID-19
  • cardiac catheterization
  • pediatric clinical cardiology
  • percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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