The impact of cell adhesion changes on proliferation and survival during prostate cancer development and progression

Beatrice S. Knudsen, Cindy K. Miranti

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

In the normal prostate epithelium, androgen receptor (AR) negative basal epithelial cells adhere to the substratum, while AR expressing secretory cells lose substratum adhesion. In contrast, prostate cancer cells both express AR and adhere to a tumor basement membrane. In this review, we describe the differential expression of integrins, growth factor receptors (GFRs), and AR in normal and cancerous epithelium. In addition, we discuss how signals from integrins, GFRs, and AR are integrated to regulate the proliferation and survival of normal and malignant prostate epithelial cells. While cell adhesion is likely of great importance when considering therapeutic approaches for treatment of metastatic prostate cancer, no data on integrin expression are available from tissues of prostate cancer metastasis. However, several drug targets that are upregulated after androgen ablative therapy regulate cell adhesion and thus novel targeted therapies indirectly interfere with cell adhesion mechanisms in prostate cancer cells.

Original languageEnglish (US)
Pages (from-to)345-361
Number of pages17
JournalJournal of Cellular Biochemistry
Volume99
Issue number2
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Keywords

  • Androgen receptor
  • Growth factor receptors
  • Integrins
  • Prostate cancer
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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