TY - JOUR
T1 - The heritability of strabismus
AU - Cross, H. E.
PY - 1975
Y1 - 1975
N2 - The familial nature of simple strabismus has led to numerous hypotheses regarding its inheritance. The highly variable clinical manifestations and the lack of specific diagnosis criteria for the classification of strabismus have, however, led to generally inconclusive and conflicting results. Of the three major mechanisms known to result in genetic disease, only multifactorial inheritance satisfactorily accounts for the observed distribution of most familial cases. Nevertheless, proof of this mechanism remains to be established since most investigations lack sufficient pedigree data. With the aid of more quantitative strabismus measurements together with expanded pedigree and population data collections, it is reasonable to anticipate clarification of the role of genetic factors in the etiology of strabismus in the near future.
AB - The familial nature of simple strabismus has led to numerous hypotheses regarding its inheritance. The highly variable clinical manifestations and the lack of specific diagnosis criteria for the classification of strabismus have, however, led to generally inconclusive and conflicting results. Of the three major mechanisms known to result in genetic disease, only multifactorial inheritance satisfactorily accounts for the observed distribution of most familial cases. Nevertheless, proof of this mechanism remains to be established since most investigations lack sufficient pedigree data. With the aid of more quantitative strabismus measurements together with expanded pedigree and population data collections, it is reasonable to anticipate clarification of the role of genetic factors in the etiology of strabismus in the near future.
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U2 - 10.1080/0065955x.1975.11982363
DO - 10.1080/0065955x.1975.11982363
M3 - Article
C2 - 1200455
AN - SCOPUS:0016588408
SN - 0065-955X
VL - Vol.25
SP - 11
EP - 17
JO - American Orthoptic Journal
JF - American Orthoptic Journal
ER -