The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation

Tania Rahim, Madison A. Levinson, Kelly E.W. Carufe, Matthew Burak, Rithy Meas, Stephen Maher, Alfred L.M. Bothwell, Naomi Gades, Joann B. Sweasy

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We previously showed that the POLBY265C/C mutation, which results in development of an aberrant immune repertoire, leads to lupus-like disease in mice. To address whether the hematopoietic compartment is sufficient for lupus development, we transplanted bone marrow cells from POLBY265C/C and POLB+/+ into wild-type congenic mice. Only mice transplanted with the POLBY265C/C bone marrow develop high levels of antinuclear antibodies and renal disease. In conclusion, we show that the hematopoietic compartment harvested from the POLBY265C/C mice is sufficient for development of autoimmune disease.

Original languageEnglish (US)
Article numbere0267913
JournalPloS one
Volume17
Issue number4 April
DOIs
StatePublished - Apr 2022
Externally publishedYes

ASJC Scopus subject areas

  • General

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