The genomic origins of the world's first farmers

Nina Marchi, Laura Winkelbach, Ilektra Schulz, Maxime Brami, Zuzana Hofmanová, Jens Blöcher, Carlos S. Reyna-Blanco, Yoan Diekmann, Alexandre Thiéry, Adamandia Kapopoulou, Vivian Link, Valérie Piuz, Susanne Kreutzer, Sylwia M. Figarska, Elissavet Ganiatsou, Albert Pukaj, Travis J. Struck, Ryan N. Gutenkunst, Necmi Karul, Fokke GerritsenJoachim Pechtl, Joris Peters, Andrea Zeeb-Lanz, Eva Lenneis, Maria Teschler-Nicola, Sevasti Triantaphyllou, Sofija Stefanović, Christina Papageorgopoulou, Daniel Wegmann, Joachim Burger, Laurent Excoffier

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their differentiation, remain largely unknown. Demogenomic modeling of high-quality ancient genomes reveals that the early farmers of Anatolia and Europe emerged from a multiphase mixing of a Southwest Asian population with a strongly bottlenecked western hunter-gatherer population after the last glacial maximum. Moreover, the ancestors of the first farmers of Europe and Anatolia went through a period of extreme genetic drift during their westward range expansion, contributing highly to their genetic distinctiveness. This modeling elucidates the demographic processes at the root of the Neolithic transition and leads to a spatial interpretation of the population history of Southwest Asia and Europe during the late Pleistocene and early Holocene.

Original languageEnglish (US)
Pages (from-to)1842-1859.e18
JournalCell
Volume185
Issue number11
DOIs
StatePublished - May 26 2022

Keywords

  • Neolithic transition
  • ancient genomics
  • demogenomic modeling
  • demographic inference
  • demographic processes
  • human evolution
  • population admixture
  • upper Palaeolithic

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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