The genomic origins of the world's first farmers

Nina Marchi; Laura Winkelbach; Ilektra Schulz; Maxime Brami; Zuzana Hofmanová; Jens Blöcher; Carlos S. Reyna-Blanco; Yoan Diekmann; Alexandre Thiéry; Adamandia Kapopoulou; Vivian Link; Valérie Piuz; Susanne Kreutzer; Sylwia M. Figarska; Elissavet Ganiatsou; Albert Pukaj; Travis J. Struck; Ryan N. Gutenkunst; Necmi Karul; Fokke Gerritsen; Joachim Pechtl; Joris Peters; Andrea Zeeb-Lanz; Eva Lenneis; Maria Teschler-Nicola; Sevasti Triantaphyllou; Sofija Stefanović; Christina Papageorgopoulou; Daniel Wegmann; Joachim Burger; Laurent Excoffier

doi:10.1016/j.cell.2022.04.008

The genomic origins of the world's first farmers

Nina Marchi, Laura Winkelbach, Ilektra Schulz, Maxime Brami, Zuzana Hofmanová, Jens Blöcher, Carlos S. Reyna-Blanco, Yoan Diekmann, Alexandre Thiéry, Adamandia Kapopoulou, Vivian Link, Valérie Piuz, Susanne Kreutzer, Sylwia M. Figarska, Elissavet Ganiatsou, Albert Pukaj, Travis J. Struck, Ryan N. Gutenkunst, Necmi Karul, Fokke GerritsenJoachim Pechtl, Joris Peters, Andrea Zeeb-Lanz, Eva Lenneis, Maria Teschler-Nicola, Sevasti Triantaphyllou, Sofija Stefanović, Christina Papageorgopoulou, Daniel Wegmann, Joachim Burger, Laurent Excoffier

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their differentiation, remain largely unknown. Demogenomic modeling of high-quality ancient genomes reveals that the early farmers of Anatolia and Europe emerged from a multiphase mixing of a Southwest Asian population with a strongly bottlenecked western hunter-gatherer population after the last glacial maximum. Moreover, the ancestors of the first farmers of Europe and Anatolia went through a period of extreme genetic drift during their westward range expansion, contributing highly to their genetic distinctiveness. This modeling elucidates the demographic processes at the root of the Neolithic transition and leads to a spatial interpretation of the population history of Southwest Asia and Europe during the late Pleistocene and early Holocene.

Original language	English (US)
Pages (from-to)	1842-1859.e18
Journal	Cell
Volume	185
Issue number	11
DOIs	https://doi.org/10.1016/j.cell.2022.04.008
State	Published - May 26 2022
Externally published	Yes

Keywords

Neolithic transition
ancient genomics
demogenomic modeling
demographic inference
demographic processes
human evolution
population admixture
upper Palaeolithic

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2022.04.008

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Marchi, N., Winkelbach, L., Schulz, I., Brami, M., Hofmanová, Z., Blöcher, J., Reyna-Blanco, C. S., Diekmann, Y., Thiéry, A., Kapopoulou, A., Link, V., Piuz, V., Kreutzer, S., Figarska, S. M., Ganiatsou, E., Pukaj, A., Struck, T. J., Gutenkunst, R. N., Karul, N., ... Excoffier, L. (2022). The genomic origins of the world's first farmers. Cell, 185(11), 1842-1859.e18. https://doi.org/10.1016/j.cell.2022.04.008

Marchi, N, Winkelbach, L, Schulz, I, Brami, M, Hofmanová, Z, Blöcher, J, Reyna-Blanco, CS, Diekmann, Y, Thiéry, A, Kapopoulou, A, Link, V, Piuz, V, Kreutzer, S, Figarska, SM, Ganiatsou, E, Pukaj, A, Struck, TJ, Gutenkunst, RN, Karul, N, Gerritsen, F, Pechtl, J, Peters, J, Zeeb-Lanz, A, Lenneis, E, Teschler-Nicola, M, Triantaphyllou, S, Stefanović, S, Papageorgopoulou, C, Wegmann, D, Burger, J & Excoffier, L 2022, 'The genomic origins of the world's first farmers', Cell, vol. 185, no. 11, pp. 1842-1859.e18. https://doi.org/10.1016/j.cell.2022.04.008

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title = "The genomic origins of the world's first farmers",

abstract = "The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their differentiation, remain largely unknown. Demogenomic modeling of high-quality ancient genomes reveals that the early farmers of Anatolia and Europe emerged from a multiphase mixing of a Southwest Asian population with a strongly bottlenecked western hunter-gatherer population after the last glacial maximum. Moreover, the ancestors of the first farmers of Europe and Anatolia went through a period of extreme genetic drift during their westward range expansion, contributing highly to their genetic distinctiveness. This modeling elucidates the demographic processes at the root of the Neolithic transition and leads to a spatial interpretation of the population history of Southwest Asia and Europe during the late Pleistocene and early Holocene.",

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AU - Blöcher, Jens

AU - Reyna-Blanco, Carlos S.

AU - Diekmann, Yoan

AU - Thiéry, Alexandre

AU - Kapopoulou, Adamandia

AU - Link, Vivian

AU - Piuz, Valérie

AU - Kreutzer, Susanne

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AU - Ganiatsou, Elissavet

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AU - Gerritsen, Fokke

AU - Pechtl, Joachim

AU - Peters, Joris

AU - Zeeb-Lanz, Andrea

AU - Lenneis, Eva

AU - Teschler-Nicola, Maria

AU - Triantaphyllou, Sevasti

AU - Stefanović, Sofija

AU - Papageorgopoulou, Christina

AU - Wegmann, Daniel

AU - Burger, Joachim

AU - Excoffier, Laurent

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KW - Neolithic transition

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KW - demogenomic modeling

KW - demographic inference

KW - demographic processes

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The genomic origins of the world's first farmers

Abstract

Keywords

ASJC Scopus subject areas

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