The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis

Simon B. Goldberg, Brian T. Pace, Christopher R. Nicholas, Charles L. Raison, Paul R. Hutson

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The current meta-analysis examined the effects of psilocybin in combination with behavioral interventions on anxiety and depression in samples with elevated symptoms. Across four studies (one uncontrolled; three randomized, placebo-controlled; N = 117), within-group pre-post and pre-follow-up effects on anxiety and depression were large (Hedges’ gs=1.16 to 1.47) and statistically significant. Across three placebo-controlled studies, pre-post placebo-controlled effects were also large (gs = 0.82 to 0.83) and statistically significant. No serious adverse events were reported. Limitations include the small number of studies and risk for bias within studies. Results tentatively support future research on psilocybin for the treatment of anxiety and depression.

Original languageEnglish (US)
Article number112749
JournalPsychiatry research
Volume284
DOIs
StatePublished - Feb 2020

Keywords

  • Anxiety
  • Depression
  • Psilocybin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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