The evolving nature of "infantile obstructive cholangiopathy"

Fayez K. Ghishan, Douglas R. LaBrecque, Frank A. Mitros, M. Kabir Younoszai

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


We report four patients with neonatal conjugated hyperbilirubinemia in whom the nature of the disease varied from that predicted by the initial diagnostic work-up. In two the initial liver biopsy showed paucity of the intrahepatic bile ducts; one cleared her conjugated hyperbilirubinemia and appeared normal at 3 years, but the other proved to have extrahepatic biliary atresia. The initial liver biospy in two additional patients showed bile duct proliferation; both patients had a paucity of intrahepatic bile ducts later in the course of their disease. These cases illustrate the necessity of carefully following patients with neonatal conjugated hyperbilirubinemia to be certain that their courses continue to conform to the original diagnoses.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalThe Journal of Pediatrics
Issue number1
StatePublished - Jul 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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