The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol

Daniel Woo, Jonathan Rosand, Chelsea Kidwell, Jacob L. Mccauley, Jennifer Osborne, Mark W. Brown, Sandra E. West, Eric W. Rademacher, Salina Waddy, Jamie N. Roberts, Sebastian Koch, Nicole R. Gonzales, Gene Sung, Steven J. Kittner, Lee Birnbaum, Michael Frankel, Fernando Daniel Testai, Christiana E. Hall, Mitchell S.V. Elkind, Matthew FlahertyBruce Coull, Ji Y. Chong, Tanya Warwick, Marc Malkoff, Michael L. James, Latisha K. Ali, Bradford B. Worrall, Floyd Jones, Tiffany Watson, Anne Leonard, Rebecca Martinez, Ralph I. Sacco, Carl D. Langefeld

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Background and Purpose-Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. Methods-The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case- control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region. Results-As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. Conclusions-The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.

Original languageEnglish (US)
Pages (from-to)e120-e125
Issue number10
StatePublished - Oct 2013


  • Cerebral hemorrhage
  • Genetics
  • Genomics
  • Hypertension
  • Minority groups
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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