The endothelial glycocalyx: Emerging concepts in pulmonary edema and acute lung injury

Stephen R. Collins; Randal S. Blank; Lindy S. Deatherage; Randal O. Dull

doi:10.1213/ANE.0b013e3182975b85

The endothelial glycocalyx: Emerging concepts in pulmonary edema and acute lung injury

Stephen R. Collins, Randal S. Blank, Lindy S. Deatherage, Randal O. Dull

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The endothelial glycocalyx is a dynamic layer of macromolecules at the luminal surface of vascular endothelium that is involved in fluid homeostasis and regulation. Its role in vascular permeability and edema formation is emerging but is still not well understood. In this special article, we highlight key concepts of endothelial dysfunction with regards to the glycocalyx and provide new insights into the glycocalyx as a mediator of processes central to the development of pulmonary edema and lung injury.

Original language	English (US)
Pages (from-to)	664-674
Number of pages	11
Journal	Anesthesia and analgesia
Volume	117
Issue number	3
DOIs	https://doi.org/10.1213/ANE.0b013e3182975b85
State	Published - Sep 2013
Externally published	Yes

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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The endothelial glycocalyx: Emerging concepts in pulmonary edema and acute lung injury

Abstract

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