The emergence of genome-based drug repositioning

Yves A. Lussier, James L. Chen

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


In a pair of papers in this issue of Science Translational Medicine, Butte et al. provide a concrete example of how reinterpreting and comparing genome-wide metrics allows us to effectively hypothesize which drugs from one disease-indication can be repurposed for another disease. The shift toward integrative genome-wide computational approaches has precedence in insightful scalar theories of biological information. Here, we discuss how this recent work in drug repurposing adheres to and takes advantage of the concepts surrounding this information paradigm.

Original languageEnglish (US)
Article number96ps35
JournalScience translational medicine
Issue number96
StatePublished - Aug 17 2011

ASJC Scopus subject areas

  • General Medicine


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