The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes

R. L. Friedman; J. E. Lochner; R. H. Bigley; B. H. Iglewski

doi:10.1093/infdis/146.3.328

The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes

R. L. Friedman, J. E. Lochner, R. H. Bigley, B. H. Iglewski

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The effect of Legionella pneumophila toxin on selected functions of human polymorphonuclear leukocytes was investigated. Amounts of L. pneumophila toxin that had no effect on leukocyte viability or phagocytosis significantly decreased hexose monophosphate shunt activity and O₂ consumption during phagocytosis and bacterial iodination and killing in a dose-dependent fashion. The mechanism of action of this toxin appears to be unique among bacterial products thus far studied.

Original language	English (US)
Pages (from-to)	328-334
Number of pages	7
Journal	Journal of Infectious Diseases
Volume	146
Issue number	3
DOIs	https://doi.org/10.1093/infdis/146.3.328
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/146.3.328

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abstract = "The effect of Legionella pneumophila toxin on selected functions of human polymorphonuclear leukocytes was investigated. Amounts of L. pneumophila toxin that had no effect on leukocyte viability or phagocytosis significantly decreased hexose monophosphate shunt activity and O2 consumption during phagocytosis and bacterial iodination and killing in a dose-dependent fashion. The mechanism of action of this toxin appears to be unique among bacterial products thus far studied.",

author = "Friedman, {R. L.} and Lochner, {J. E.} and Bigley, {R. H.} and Iglewski, {B. H.}",

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The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes

Abstract

ASJC Scopus subject areas

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