The effects of gossypol on the antioxidant defense system of the rat liver

H. S. Bender, H. P. Misra

Research output: Contribution to journalArticlepeer-review


Rats were dosed with gossypol acetic acid by subcutaneous injection or gavage to determine its effect on some of the key antioxidant defense systems of the liver. Gossypol, a pigment of cottonseeds, is a known hepatoxin and antifertility agent, but its mechanism of action is presently unknown. The hepatic antioxidants catalase, ascorbate, α-tocopherol, glutathione peroxidase glutathion, glutathione reductase, copper-zinc superoxide dismutase, manganese superoxide dismutase and glucose-t-phosphate dehydrogenase were assayed in this study. Of these 9 antioxidants, catalase, ascorbate, glutathione peroxidase and copper-zinc superoxide dismutase were significantly reduced in the livers of both injected and gavaged rats compared to the respective controls. Deficiency of these key antioxidants would make hepatocytes highly vulnerable to oxidative injury. Thus, oxidative injury may be central to the pathogenesis of gossypol induced hepatic necrosis.

Original languageEnglish (US)
Pages (from-to)369-388
Number of pages20
JournalAdvances in Contraceptive Delivery Systems
Issue number3-4
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'The effects of gossypol on the antioxidant defense system of the rat liver'. Together they form a unique fingerprint.

Cite this