The effects of daily consumption of grapefruit on body weight, lipids, and blood pressure in healthy, overweight adults

Caitlin A. Dow, Scott B. Going, Hsiao Hui S. Chow, Bhimanagouda S. Patil, Cynthia A. Thomson

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Folklore has suggested that consuming grapefruit may promote weight control. Sparse data exist to support this hypothesis, although there is some evidence of health promotion effects with regard to blood pressure control and modulation of circulating lipids. The aim of this randomized controlled trial was to prospectively evaluate the role of grapefruit in reducing body weight and blood pressure and in promoting improvements in the lipid profile in overweight adults (N = 74). Following a 3-week washout diet low in bioactive-rich fruits and vegetables, participants were randomized to either the control diet (n = 32) or daily grapefruit (n = 42) in the amount of one half of a fresh Rio-Red grapefruit with each meal (3× daily) for 6 weeks. No differences between group in weight, blood pressure, or lipids were demonstrated. Grapefruit consumption was associated with modest weight loss (-0.61 ± 2.23 kg, P =.097), a significant reduction in waist circumference (-2.45 ± 0.60 cm, P =.0002), and a significant reduction in systolic blood pressure (-3.21 ± 10.13 mm Hg, P =.03) compared with baseline values. Improvements were observed in circulating lipids of those consuming grapefruit, with total cholesterol and low-density lipoprotein significantly decreasing by -11.7 mg/dL (P =.002) and -18.7 mg/dL (P <.001), respectively, compared with baseline values. This study suggests that consumption of grapefruit daily for 6 weeks does not significantly decrease body weight, lipids, or blood pressure as compared with the control condition. However, the improvements in blood pressure and lipids demonstrated in the intervention group suggest that grapefruit should be further evaluated in the context of obesity and cardiovascular disease prevention.

Original languageEnglish (US)
Pages (from-to)1026-1035
Number of pages10
JournalMetabolism: Clinical and Experimental
Issue number7
StatePublished - Jul 2012

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'The effects of daily consumption of grapefruit on body weight, lipids, and blood pressure in healthy, overweight adults'. Together they form a unique fingerprint.

Cite this