The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study

Terence N. Moore; Robert Livingston; Lance Heilbrun; James Eltringham; Odis Skinner; Joel White; Donald Tesh

doi:10.1002/1097-0142(197806)41:6<2149::AID-CNCR2820410611>3.0.CO;2-P

The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study

Terence N. Moore, Robert Livingston, Lance Heilbrun, James Eltringham, Odis Skinner, Joel White, Donald Tesh

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Abstract

Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG) began treating patients with combination chemotherapy and irradiation of both the primary lesion and whole brain. In two years, there were 390 patients entered into the study. In patients with extensive disease only 6 of 152 prophylactically irradiated patients developed CNS signs or symptoms of CNS recurrence. In limited disease, 6 of 88 prophylactically treated patients had CNS recurrence and in only 4 was this the site of initial failure. We feel prophylactic brain irradiation in small cell carcinoma of the lung is of benefit.

Original language	English (US)
Pages (from-to)	2149-2153
Number of pages	5
Journal	Cancer
Volume	41
Issue number	6
DOIs	https://doi.org/10.1002/1097-0142(197806)41:6<2149::AID-CNCR2820410611>3.0.CO;2-P
State	Published - Jun 1978
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(197806)41:6<2149::AID-CNCR2820410611>3.0.CO;2-P

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title = "The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study",

abstract = "Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG) began treating patients with combination chemotherapy and irradiation of both the primary lesion and whole brain. In two years, there were 390 patients entered into the study. In patients with extensive disease only 6 of 152 prophylactically irradiated patients developed CNS signs or symptoms of CNS recurrence. In limited disease, 6 of 88 prophylactically treated patients had CNS recurrence and in only 4 was this the site of initial failure. We feel prophylactic brain irradiation in small cell carcinoma of the lung is of benefit.",

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T1 - The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study

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AU - Heilbrun, Lance

AU - Eltringham, James

AU - Skinner, Odis

AU - White, Joel

AU - Tesh, Donald

PY - 1978/6

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N2 - Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG) began treating patients with combination chemotherapy and irradiation of both the primary lesion and whole brain. In two years, there were 390 patients entered into the study. In patients with extensive disease only 6 of 152 prophylactically irradiated patients developed CNS signs or symptoms of CNS recurrence. In limited disease, 6 of 88 prophylactically treated patients had CNS recurrence and in only 4 was this the site of initial failure. We feel prophylactic brain irradiation in small cell carcinoma of the lung is of benefit.

AB - Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG) began treating patients with combination chemotherapy and irradiation of both the primary lesion and whole brain. In two years, there were 390 patients entered into the study. In patients with extensive disease only 6 of 152 prophylactically irradiated patients developed CNS signs or symptoms of CNS recurrence. In limited disease, 6 of 88 prophylactically treated patients had CNS recurrence and in only 4 was this the site of initial failure. We feel prophylactic brain irradiation in small cell carcinoma of the lung is of benefit.

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The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study

Abstract

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