Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge.

N. K. Popova; N. N. Voǐtenko; A. V. Kulikov; E. M. Nikulina; G. B. Vishnevetskaia; O. V. Trapezov

Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge.

Translated title of the contribution: The effect of the pleiotropic action of single-locus (pp) and dual-locus (aapp) mutation of mink fur color genes on serotonin metabolism in the brain

N. K. Popova, N. N. Voǐtenko, A. V. Kulikov, E. M. Nikulina, G. B. Vishnevetskaia, O. V. Trapezov

Basic Medical Sciences, Phoenix

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Specific features of serotonin (5-hydroxytryptamine, 5-HT) metabolism were studied in the brain of mutant sapphire minks, homozygous at genes determining silver-blue and Aleutian fur color (ppaa), and silver-blue minks (pp) in comparison with the standard-colored minks (++/++). In the midbrain of sapphire mutants, the activities of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO), key enzymes of 5-HT biosynthesis and catabolism, were significantly higher; an increase in the 5-HT level was statistically nonsignificant due to considerable variation in this parameter; and the level of 5-hydroxyindole-3-acetic acid remained unchanged. A similar increase in TPH and MAO activities was also found in the midbrain of silver-blue pp minks, suggesting that activation of key enzymes of 5-HT metabolism in sapphire aapp minks is associated with the mutant alleles pp.

Translated title of the contribution	The effect of the pleiotropic action of single-locus (pp) and dual-locus (aapp) mutation of mink fur color genes on serotonin metabolism in the brain
Original language	Russian
Pages (from-to)	1513-1515
Number of pages	3
Journal	Genetika
Volume	30
Issue number	11
State	Published - Nov 1994

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge.",

abstract = "Specific features of serotonin (5-hydroxytryptamine, 5-HT) metabolism were studied in the brain of mutant sapphire minks, homozygous at genes determining silver-blue and Aleutian fur color (ppaa), and silver-blue minks (pp) in comparison with the standard-colored minks (++/++). In the midbrain of sapphire mutants, the activities of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO), key enzymes of 5-HT biosynthesis and catabolism, were significantly higher; an increase in the 5-HT level was statistically nonsignificant due to considerable variation in this parameter; and the level of 5-hydroxyindole-3-acetic acid remained unchanged. A similar increase in TPH and MAO activities was also found in the midbrain of silver-blue pp minks, suggesting that activation of key enzymes of 5-HT metabolism in sapphire aapp minks is associated with the mutant alleles pp.",

author = "Popova, {N. K.} and Voǐtenko, {N. N.} and Kulikov, {A. V.} and Nikulina, {E. M.} and Vishnevetskaia, {G. B.} and Trapezov, {O. V.}",

year = "1994",

month = nov,

language = "Russian",

volume = "30",

pages = "1513--1515",

journal = "Genetika",

issn = "0016-6758",

publisher = "Maik Nauka-Interperiodica Publishing",

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T1 - Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge.

AU - Popova, N. K.

AU - Voǐtenko, N. N.

AU - Kulikov, A. V.

AU - Nikulina, E. M.

AU - Vishnevetskaia, G. B.

AU - Trapezov, O. V.

PY - 1994/11

Y1 - 1994/11

N2 - Specific features of serotonin (5-hydroxytryptamine, 5-HT) metabolism were studied in the brain of mutant sapphire minks, homozygous at genes determining silver-blue and Aleutian fur color (ppaa), and silver-blue minks (pp) in comparison with the standard-colored minks (++/++). In the midbrain of sapphire mutants, the activities of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO), key enzymes of 5-HT biosynthesis and catabolism, were significantly higher; an increase in the 5-HT level was statistically nonsignificant due to considerable variation in this parameter; and the level of 5-hydroxyindole-3-acetic acid remained unchanged. A similar increase in TPH and MAO activities was also found in the midbrain of silver-blue pp minks, suggesting that activation of key enzymes of 5-HT metabolism in sapphire aapp minks is associated with the mutant alleles pp.

AB - Specific features of serotonin (5-hydroxytryptamine, 5-HT) metabolism were studied in the brain of mutant sapphire minks, homozygous at genes determining silver-blue and Aleutian fur color (ppaa), and silver-blue minks (pp) in comparison with the standard-colored minks (++/++). In the midbrain of sapphire mutants, the activities of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO), key enzymes of 5-HT biosynthesis and catabolism, were significantly higher; an increase in the 5-HT level was statistically nonsignificant due to considerable variation in this parameter; and the level of 5-hydroxyindole-3-acetic acid remained unchanged. A similar increase in TPH and MAO activities was also found in the midbrain of silver-blue pp minks, suggesting that activation of key enzymes of 5-HT metabolism in sapphire aapp minks is associated with the mutant alleles pp.

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M3 - Article

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AN - SCOPUS:0028544786

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JO - Genetika

JF - Genetika

IS - 11

ER -

Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge.

Abstract

ASJC Scopus subject areas

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