The effect of intraperitoneal administration of sodium tolmetin-hyaluronic acid on the postsurgical cell infiltration in vivo

Hiromasa Abe, Kathleen E. Rodgers, Joseph D. Campeau, Wefki Girgis, Dolph Ellefson, Gere S. DiZerega

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Intraperitoneal administration of sodium tolmetinhyaluronic acid reduced the formation of adhesions at early postsurgical time points. In addition, at 6, 48, 72, and 96 hr following surgery, there was a significant reduction in the number of red blood cells (RBC) recovered from peritoneal lavage. This effect was not the result of fluid or viscous solution in the peritoneal cavity since intraperitoneal administration of Ringer's lactate or Hyskon (a 32% solution of Dextran 70) did not affect RBC recovery. In contrast, the influx of leukocytes into the peritoneal cavity was elevated at 12 hr after surgery, but suppressed at 96 hr. These data may suggest a mechanism by which sodium tolmetin in hyaluronic acid reduced adhesion formation.

Original languageEnglish (US)
Pages (from-to)322-327
Number of pages6
JournalJournal of Surgical Research
Volume49
Issue number4
DOIs
StatePublished - Oct 1990
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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