Abstract
The influence of leptin on the secretion of pancreatic juice was examined in biliary-pancreatic duct-cannulated anaesthetised rats. Exogenous leptin was given in boluses either intravenously or intraduodenally. A low dose of leptin (0.1 μg/kg BW) had no effect on pancreatic secretion. Leptin in a dose of 1 μg/kg BW given intravenously inhibited protein and amylase output only when the exocrine pancreas was stimulated by CCK-8 (12 pmol/kg BW, iv). Leptin in a high, pharmacological dose (10 μg/kg BW) given intravenously inhibited juice secretion, protein and amylase output, whereas given intraduodenally, stimulated them. Intravenous infusion of 2-deoxy-glucose (0.25 g/kg BW per h) induced pancreatic juice secretion, which was abolished by a leptin bolus (10 μg/kg BW). In conclusion, leptin can regulate the exocrine pancreas via different mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 353-363 |
| Number of pages | 11 |
| Journal | Journal of Animal and Feed Sciences |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2005 |
| Externally published | Yes |
Keywords
- Leptin
- Pancreas
- Pancreatic secretion
- Rat
ASJC Scopus subject areas
- Food Science
- Animal Science and Zoology
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