The effect of estrogen on the incorporation of 3H thymidine by PHA stimulated human peripheral blood lymphocytes

R. J. Ablin, G. R. Bruns, P. Guinan, I. M. Bush

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

The incorporation of 3H thymidine by PHA stimulated human peripheral blood lymphocytes from healthy adult males was significantly (p 0.002) suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of blastogenesis in the presence of exogenous estrogen suggests that the palliative effects of estrogenic therapy in the clinical treatment of patients with hormonally responsive tumors may be countered by its adverse effect of the host's cell mediated immunologic responsiveness (27 references).

Original languageEnglish (US)
Pages (from-to)705-707
Number of pages3
JournalJournal of Immunology
Volume113
Issue number2
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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