The effect of estrogen on the incorporation of 3H thymidine by PHA stimulated human peripheral blood lymphocytes

R. J. Ablin; G. R. Bruns; P. Guinan; I. M. Bush

The effect of estrogen on the incorporation of ³H thymidine by PHA stimulated human peripheral blood lymphocytes

R. J. Ablin, G. R. Bruns, P. Guinan, I. M. Bush

Research output: Contribution to journal › Article › peer-review

Abstract

The incorporation of ³H thymidine by PHA stimulated human peripheral blood lymphocytes from healthy adult males was significantly (p 0.002) suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of blastogenesis in the presence of exogenous estrogen suggests that the palliative effects of estrogenic therapy in the clinical treatment of patients with hormonally responsive tumors may be countered by its adverse effect of the host's cell mediated immunologic responsiveness (27 references).

Original language	English (US)
Pages (from-to)	705-707
Number of pages	3
Journal	Journal of Immunology
Volume	113
Issue number	2
State	Published - 1974
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "The effect of estrogen on the incorporation of 3H thymidine by PHA stimulated human peripheral blood lymphocytes",

abstract = "The incorporation of 3H thymidine by PHA stimulated human peripheral blood lymphocytes from healthy adult males was significantly (p 0.002) suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of blastogenesis in the presence of exogenous estrogen suggests that the palliative effects of estrogenic therapy in the clinical treatment of patients with hormonally responsive tumors may be countered by its adverse effect of the host's cell mediated immunologic responsiveness (27 references).",

author = "Ablin, {R. J.} and Bruns, {G. R.} and P. Guinan and Bush, {I. M.}",

year = "1974",

language = "English (US)",

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pages = "705--707",

journal = "Journal of Immunology",

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publisher = "American Association of Immunologists",

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AU - Guinan, P.

AU - Bush, I. M.

PY - 1974

Y1 - 1974

N2 - The incorporation of 3H thymidine by PHA stimulated human peripheral blood lymphocytes from healthy adult males was significantly (p 0.002) suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of blastogenesis in the presence of exogenous estrogen suggests that the palliative effects of estrogenic therapy in the clinical treatment of patients with hormonally responsive tumors may be countered by its adverse effect of the host's cell mediated immunologic responsiveness (27 references).

AB - The incorporation of 3H thymidine by PHA stimulated human peripheral blood lymphocytes from healthy adult males was significantly (p 0.002) suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of blastogenesis in the presence of exogenous estrogen suggests that the palliative effects of estrogenic therapy in the clinical treatment of patients with hormonally responsive tumors may be countered by its adverse effect of the host's cell mediated immunologic responsiveness (27 references).

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The effect of estrogen on the incorporation of ³H thymidine by PHA stimulated human peripheral blood lymphocytes

Abstract

ASJC Scopus subject areas

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