Abstract
The in vivo effect of cobra venom factor (CVF) on murine alternative complement pathway hemolytic activity was measured with a recently developed microassay. Four different dosage schedules of CVF were compared. Hemolytic titers were lowered to less than 5% of the baseline value by 6 hours after the first dose of CVF (62.5 - 200 U/kg), and remained low for 3-5 days, depending upon total dose, route and schedule of CVF administration. Titers at days 6-9 after initial CVF injection increased above baseline in animals given two doses of CVF separated by 48 hours.
Original language | English (US) |
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Pages (from-to) | 277-281 |
Number of pages | 5 |
Journal | Immunological Investigations |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - 1980 |
ASJC Scopus subject areas
- Immunology