The effect of alpha adrenergic blockade on non-specific airways reactivity and exercise induced asthma

E. R. Bleecker, K. S. Chahal, P. Mason, S. Permutt

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In asthmatic, alpha-adrenergic blockage with oral phentolamine partially or completely blocked bronchospasm after maximal exercise challenge. Bronchial reactivity to isocapneic hyperventilation with conditioned cold air was also reduced. However, non-specific airways reactivity to inhaled histamine did not change. Therefore, exercise and cold induced bronchospasm in asthma may be partially mediated by alpha adrenergic neural mechanisms perhaps through sensitization of alpha receptors during airway cooling.

Original languageEnglish (US)
Pages (from-to)258-265
Number of pages8
JournalEuropean Journal of Respiratory Diseases
Volume64
Issue numberSuppl. 128I
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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