The effect of α-adrenergic and antihistaminic blockade on conditioned cold air and exercise-induced asthma

S. M. Walden, E. J. Britt, S. Permutt, E. R. Bleecker

Research output: Contribution to journalArticlepeer-review

Abstract

Similar physiologic changes can be shown to occur during exercise and cold, dry air challenges. Both are inhibited by α-adrenergic blockade, suggesting that α-adrenergic mechanisms may be activated during cooling and drying of the airways. In contrast, H1 histamine receptor blockade partially or completely prevented bronchospasm induced by cold air hyperventilation without affecting the response to exercise. This divergent response to antihistamines suggests that different mechanisms may be important in mediating exercise- and cold air-induced bronchospasm despite their common initiating stimuli.

Original languageEnglish (US)
Pages (from-to)195S-197S
JournalCHEST
Volume87
Issue number5 SUPPL.
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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