The effect of α-adrenergic and antihistaminic blockade on conditioned cold air and exercise-induced asthma

S. M. Walden; E. J. Britt; S. Permutt; E. R. Bleecker

doi:10.1378/chest.87.5_Supplement.195S

The effect of α-adrenergic and antihistaminic blockade on conditioned cold air and exercise-induced asthma

S. M. Walden, E. J. Britt, S. Permutt, E. R. Bleecker

Research output: Contribution to journal › Article › peer-review

Abstract

Similar physiologic changes can be shown to occur during exercise and cold, dry air challenges. Both are inhibited by α-adrenergic blockade, suggesting that α-adrenergic mechanisms may be activated during cooling and drying of the airways. In contrast, H₁ histamine receptor blockade partially or completely prevented bronchospasm induced by cold air hyperventilation without affecting the response to exercise. This divergent response to antihistamines suggests that different mechanisms may be important in mediating exercise- and cold air-induced bronchospasm despite their common initiating stimuli.

Original language	English (US)
Pages (from-to)	195S-197S
Journal	CHEST
Volume	87
Issue number	5 SUPPL.
DOIs	https://doi.org/10.1378/chest.87.5_Supplement.195S
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

Access to Document

10.1378/chest.87.5_Supplement.195S

Cite this

@article{fbe7f0cb804d485ea6baec681a3ff53a,

title = "The effect of α-adrenergic and antihistaminic blockade on conditioned cold air and exercise-induced asthma",

abstract = "Similar physiologic changes can be shown to occur during exercise and cold, dry air challenges. Both are inhibited by α-adrenergic blockade, suggesting that α-adrenergic mechanisms may be activated during cooling and drying of the airways. In contrast, H1 histamine receptor blockade partially or completely prevented bronchospasm induced by cold air hyperventilation without affecting the response to exercise. This divergent response to antihistamines suggests that different mechanisms may be important in mediating exercise- and cold air-induced bronchospasm despite their common initiating stimuli.",

author = "Walden, {S. M.} and Britt, {E. J.} and S. Permutt and Bleecker, {E. R.}",

year = "1985",

doi = "10.1378/chest.87.5_Supplement.195S",

language = "English (US)",

volume = "87",

pages = "195S--197S",

journal = "CHEST",

issn = "0012-3692",

publisher = "Elsevier Inc.",

number = "5 SUPPL.",

}

TY - JOUR

T1 - The effect of α-adrenergic and antihistaminic blockade on conditioned cold air and exercise-induced asthma

AU - Walden, S. M.

AU - Britt, E. J.

AU - Permutt, S.

AU - Bleecker, E. R.

PY - 1985

Y1 - 1985

N2 - Similar physiologic changes can be shown to occur during exercise and cold, dry air challenges. Both are inhibited by α-adrenergic blockade, suggesting that α-adrenergic mechanisms may be activated during cooling and drying of the airways. In contrast, H1 histamine receptor blockade partially or completely prevented bronchospasm induced by cold air hyperventilation without affecting the response to exercise. This divergent response to antihistamines suggests that different mechanisms may be important in mediating exercise- and cold air-induced bronchospasm despite their common initiating stimuli.

AB - Similar physiologic changes can be shown to occur during exercise and cold, dry air challenges. Both are inhibited by α-adrenergic blockade, suggesting that α-adrenergic mechanisms may be activated during cooling and drying of the airways. In contrast, H1 histamine receptor blockade partially or completely prevented bronchospasm induced by cold air hyperventilation without affecting the response to exercise. This divergent response to antihistamines suggests that different mechanisms may be important in mediating exercise- and cold air-induced bronchospasm despite their common initiating stimuli.

UR - http://www.scopus.com/inward/record.url?scp=0022261716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022261716&partnerID=8YFLogxK

U2 - 10.1378/chest.87.5_Supplement.195S

DO - 10.1378/chest.87.5_Supplement.195S

M3 - Article

AN - SCOPUS:0022261716

SN - 0012-3692

VL - 87

SP - 195S-197S

JO - CHEST

JF - CHEST

IS - 5 SUPPL.

ER -

The effect of α-adrenergic and antihistaminic blockade on conditioned cold air and exercise-induced asthma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this