The E. coli rho protein: an ATPase that terminates transcription

David G. Bear, David S. Peabody

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The Rho protein is a toroid-shaped oligomeric ATPase that catalyses thet release of nascent RNA transcripts at discrete sites within the transcription units of E. coli and many coliphages. The signal that specifies the location of the Rho-mediated termination event appears to be quite complex. Multiple sites for Rho-subunit attachment are superimposed on a large region of the RNA transcript that contains little or no secondary structure. RNA polymerase pause sites and template-transcript interactions may also serve to define the actual locations of transcript release.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalTrends in Biochemical Sciences
Volume13
Issue number9
DOIs
StatePublished - Sep 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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