The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

Jeyaprakashnarayanan Seenisamy; Evonne M. Rezler; Tiffanie J. Powell; Denise Tye; Vijay Gokhale; Chandana Sharma Joshi; Adam Siddiqui-Jain; Laurence H. Hurley

doi:10.1021/ja040022b

The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

Jeyaprakashnarayanan Seenisamy, Evonne M. Rezler, Tiffanie J. Powell, Denise Tye, Vijay Gokhale, Chandana Sharma Joshi, Adam Siddiqui-Jain, Laurence H. Hurley

Research output: Contribution to journal › Article › peer-review

361 Scopus citations

Abstract

The nuclease hypersensitivity element III₁ (NHE III₁) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.

Original language	English (US)
Pages (from-to)	8702-8709
Number of pages	8
Journal	Journal of the American Chemical Society
Volume	126
Issue number	28
DOIs	https://doi.org/10.1021/ja040022b
State	Published - Jul 21 2004

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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abstract = "The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.",

author = "Jeyaprakashnarayanan Seenisamy and Rezler, {Evonne M.} and Powell, {Tiffanie J.} and Denise Tye and Vijay Gokhale and Joshi, {Chandana Sharma} and Adam Siddiqui-Jain and Hurley, {Laurence H.}",

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AU - Seenisamy, Jeyaprakashnarayanan

AU - Rezler, Evonne M.

AU - Powell, Tiffanie J.

AU - Tye, Denise

AU - Gokhale, Vijay

AU - Joshi, Chandana Sharma

AU - Siddiqui-Jain, Adam

AU - Hurley, Laurence H.

PY - 2004/7/21

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AB - The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.

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The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

Abstract

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