The diverse roles of sphingolipids in inflammatory bowel disease

Chelsea L. Doll, Ashley J. Snider

Research output: Contribution to journalReview articlepeer-review

Abstract

The incidence of inflammatory bowel disease (IBD) has increased over the last 20 years. A variety of causes, both physiological and environmental, contribute to the initiation and progression of IBD, making disease management challenging. Current treatment options target various aspects of the immune response to dampen intestinal inflammation; however, their effectiveness at retaining remission, their side effects, and loss of response from patients over time warrant further investigation. Finding a common thread within the multitude causes of IBD is critical in developing robust treatment options. Sphingolipids are evolutionary conserved bioactive lipids universally generated in all cell types. This diverse lipid family is involved in a variety of fundamental, yet sometimes opposing, processes such as proliferation and apoptosis. Implicated as regulators in intestinal diseases, sphingolipids are a potential cornerstone in understanding IBD. Herein we will describe the role of host- and microbial-derived sphingolipids as they relate to the many factors of intestinal health and IBD.

Original languageEnglish (US)
Article numbere23777
JournalFASEB Journal
Volume38
Issue number13
DOIs
StatePublished - Jul 15 2024

Keywords

  • Crohn's disease
  • ceramide
  • colitis
  • colitis-associated cancer
  • colorectal cancer
  • inflammation
  • inflammatory bowel disease
  • microbiome
  • sphingolipids
  • sphingosine-1-phosphate

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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