The disruptive effect of cocaine on prepulse inhibition is prevented by repeated administration in rats

John J. Byrnes; Ronald P. Hammer

doi:10.1016/S0893-133X(99)00151-7

The disruptive effect of cocaine on prepulse inhibition is prevented by repeated administration in rats

John J. Byrnes, Ronald P. Hammer

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

These experiments tested the hypothesis that pretreatment with a behaviorally sensitizing regimen of cocaine alters the ability of cocaine to disrupt prepulse inhibition (PPI). Male Sprague-Dawley rats were treated with cocaine (30 mg/kg, i.p.) or saline vehicle for seven consecutive days followed by challenge treatment seven days later. Repeated cocaine treatment produced sensitization of stereotyped activity. Cocaine challenge following repeated vehicle treatment significantly reduced PPI, but this effect was completely abolished by repeated cocaine treatment. These data suggest that neuroadaptation following repeated treatment might prevent PPI disruption caused by psychomotor stimulants. Copyright (C) 2000 American College of Neuropsychopharmacology.

Original language	English (US)
Pages (from-to)	551-554
Number of pages	4
Journal	Neuropsychopharmacology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/S0893-133X(99)00151-7
State	Published - May 2000
Externally published	Yes

Keywords

Behavioral sensitization
Cocaine
Prepulse Inhibition
Schizophrenia
Sensorimotor gating

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health

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10.1016/S0893-133X(99)00151-7

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title = "The disruptive effect of cocaine on prepulse inhibition is prevented by repeated administration in rats",

abstract = "These experiments tested the hypothesis that pretreatment with a behaviorally sensitizing regimen of cocaine alters the ability of cocaine to disrupt prepulse inhibition (PPI). Male Sprague-Dawley rats were treated with cocaine (30 mg/kg, i.p.) or saline vehicle for seven consecutive days followed by challenge treatment seven days later. Repeated cocaine treatment produced sensitization of stereotyped activity. Cocaine challenge following repeated vehicle treatment significantly reduced PPI, but this effect was completely abolished by repeated cocaine treatment. These data suggest that neuroadaptation following repeated treatment might prevent PPI disruption caused by psychomotor stimulants. Copyright (C) 2000 American College of Neuropsychopharmacology.",

keywords = "Behavioral sensitization, Cocaine, Prepulse Inhibition, Schizophrenia, Sensorimotor gating",

author = "Byrnes, {John J.} and Hammer, {Ronald P.}",

note = "Funding Information: This work was supported by USPHS Awards DA09822 (RPH) and MH19924 (JJB). The authors wish to thank Horacio Daubon and Dwight Dishmon, who were supported by HL07785, for expert assistance, and Dr. S. Barak Caine for his helpful consultation.",

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AU - Hammer, Ronald P.

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N2 - These experiments tested the hypothesis that pretreatment with a behaviorally sensitizing regimen of cocaine alters the ability of cocaine to disrupt prepulse inhibition (PPI). Male Sprague-Dawley rats were treated with cocaine (30 mg/kg, i.p.) or saline vehicle for seven consecutive days followed by challenge treatment seven days later. Repeated cocaine treatment produced sensitization of stereotyped activity. Cocaine challenge following repeated vehicle treatment significantly reduced PPI, but this effect was completely abolished by repeated cocaine treatment. These data suggest that neuroadaptation following repeated treatment might prevent PPI disruption caused by psychomotor stimulants. Copyright (C) 2000 American College of Neuropsychopharmacology.

AB - These experiments tested the hypothesis that pretreatment with a behaviorally sensitizing regimen of cocaine alters the ability of cocaine to disrupt prepulse inhibition (PPI). Male Sprague-Dawley rats were treated with cocaine (30 mg/kg, i.p.) or saline vehicle for seven consecutive days followed by challenge treatment seven days later. Repeated cocaine treatment produced sensitization of stereotyped activity. Cocaine challenge following repeated vehicle treatment significantly reduced PPI, but this effect was completely abolished by repeated cocaine treatment. These data suggest that neuroadaptation following repeated treatment might prevent PPI disruption caused by psychomotor stimulants. Copyright (C) 2000 American College of Neuropsychopharmacology.

KW - Behavioral sensitization

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KW - Schizophrenia

KW - Sensorimotor gating

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The disruptive effect of cocaine on prepulse inhibition is prevented by repeated administration in rats

Abstract

Keywords

ASJC Scopus subject areas

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