The delta opioid receptor

A. M. Symons-Liguori, T. W. Vanderah

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The delta opioid receptor has become increasingly relevant to the development of analgesics since its discovery only a few decades past. The endogenous antinociceptive properties of the δOR in conjunction with the potential for δOR ligands to circumvent classical μ-opioid side effects and tolerance make the δOR a provocative alternative to current μOR-specific strategies. This chapter explores the clinical potential of δOR-mediated analgesia and discusses novel biochemical strategies for targeting the δOR. Finally, we evaluate the use of δOR ligands as co-therapies with new and classical analgesics. A greater understanding of δOR function and pharmacology will ultimately contribute to the development of innovative new strategies for the pharmacological management of pain.

Original languageEnglish (US)
Title of host publicationResearch and Development of Opioid-Related Ligands
PublisherAmerican Chemical Society
Number of pages22
ISBN (Print)9780841227828
StatePublished - May 10 2013

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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