TY - GEN
T1 - The delta opioid receptor
AU - Symons-Liguori, A. M.
AU - Vanderah, T. W.
PY - 2013/5/10
Y1 - 2013/5/10
N2 - The delta opioid receptor has become increasingly relevant to the development of analgesics since its discovery only a few decades past. The endogenous antinociceptive properties of the δOR in conjunction with the potential for δOR ligands to circumvent classical μ-opioid side effects and tolerance make the δOR a provocative alternative to current μOR-specific strategies. This chapter explores the clinical potential of δOR-mediated analgesia and discusses novel biochemical strategies for targeting the δOR. Finally, we evaluate the use of δOR ligands as co-therapies with new and classical analgesics. A greater understanding of δOR function and pharmacology will ultimately contribute to the development of innovative new strategies for the pharmacological management of pain.
AB - The delta opioid receptor has become increasingly relevant to the development of analgesics since its discovery only a few decades past. The endogenous antinociceptive properties of the δOR in conjunction with the potential for δOR ligands to circumvent classical μ-opioid side effects and tolerance make the δOR a provocative alternative to current μOR-specific strategies. This chapter explores the clinical potential of δOR-mediated analgesia and discusses novel biochemical strategies for targeting the δOR. Finally, we evaluate the use of δOR ligands as co-therapies with new and classical analgesics. A greater understanding of δOR function and pharmacology will ultimately contribute to the development of innovative new strategies for the pharmacological management of pain.
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U2 - 10.1021/bk-2013-1131.ch012
DO - 10.1021/bk-2013-1131.ch012
M3 - Conference contribution
AN - SCOPUS:84905454968
SN - 9780841227828
T3 - ACS Symposium Series
SP - 223
EP - 244
BT - Research and Development of Opioid-Related Ligands
PB - American Chemical Society
ER -