TY - JOUR
T1 - The cost of a euploid embryo identified from preimplantation genetic testing for aneuploidy (PGT-A)
T2 - a counseling tool
AU - Goldman, Randi H.
AU - Racowsky, Catherine
AU - Farland, Leslie V.
AU - Fox, Janis H.
AU - Munné, Santiago
AU - Ribustello, Lia
AU - Ginsburg, Elizabeth S.
N1 - Funding Information:
Conflicts of interest E.G. receives royalties from UpToDate, Springer BioMed Central, Advance Medical, and Sanders and Parks and receives research funding from Serono, unrelated to this work. C.R. is an ASRM board member, receives royalties from Springer and the University of Cambridge, is a lecturer at Ferring, Inc., and is an IVF program consultant, unrelated to this work. S.M. and L. R. are employed by CooperGenomics. The remaining authors report no conflicts of interest.
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Purpose: To determine the expected out-of-pocket costs of IVF with preimplantation genetic testing for aneuploidy (PGT-A) to attain a 50%, 75%, or 90% likelihood of a euploid blastocyst based on individual age and AMH, and develop a personalized counseling tool. Methods: A cost analysis was performed and a counseling tool was developed using retrospective data from IVF cycles intended for PGT or blastocyst freeze-all between January 1, 2014 and August 31, 2017 (n = 330) and aggregate statistics on euploidy rates of > 149,000 embryos from CooperGenomics. Poisson regression was used to determine the number of biopsiable blastocysts obtained per cycle, based on age and AMH. The expected costs of attaining a 50%, 75%, and 90% likelihood of a euploid blastocyst were determined via 10,000 Monte Carlo simulations for each age and AMH combination, incorporating age-based euploidy rates and IVF/PGT-A cost assumptions. Results: The cost to attain a 50% likelihood of a euploid blastocyst ranges from approximately $15,000 U.S. dollars (USD) for younger women with higher AMH values (≥ 2 ng/mL) to > $150,000 for the oldest women (44 years) with the lowest AMH values (< 0.1 ng/mL) in this cohort. The cost to attain a 75% versus 90% likelihood of a euploid blastocyst is similar (~ $16,000) for younger women with higher AMH values, but varies for the oldest women with low AMH values (~ $280,000 and > $450,000, respectively). A typical patient (36–37 years, AMH 2.5 ng/mL) should expect to spend ~ $30,000 for a 90% likelihood of attaining a euploid embryo. Conclusions: This tool can serve as a counseling adjunct by providing individualized cost information for patients regarding PGT-A.
AB - Purpose: To determine the expected out-of-pocket costs of IVF with preimplantation genetic testing for aneuploidy (PGT-A) to attain a 50%, 75%, or 90% likelihood of a euploid blastocyst based on individual age and AMH, and develop a personalized counseling tool. Methods: A cost analysis was performed and a counseling tool was developed using retrospective data from IVF cycles intended for PGT or blastocyst freeze-all between January 1, 2014 and August 31, 2017 (n = 330) and aggregate statistics on euploidy rates of > 149,000 embryos from CooperGenomics. Poisson regression was used to determine the number of biopsiable blastocysts obtained per cycle, based on age and AMH. The expected costs of attaining a 50%, 75%, and 90% likelihood of a euploid blastocyst were determined via 10,000 Monte Carlo simulations for each age and AMH combination, incorporating age-based euploidy rates and IVF/PGT-A cost assumptions. Results: The cost to attain a 50% likelihood of a euploid blastocyst ranges from approximately $15,000 U.S. dollars (USD) for younger women with higher AMH values (≥ 2 ng/mL) to > $150,000 for the oldest women (44 years) with the lowest AMH values (< 0.1 ng/mL) in this cohort. The cost to attain a 75% versus 90% likelihood of a euploid blastocyst is similar (~ $16,000) for younger women with higher AMH values, but varies for the oldest women with low AMH values (~ $280,000 and > $450,000, respectively). A typical patient (36–37 years, AMH 2.5 ng/mL) should expect to spend ~ $30,000 for a 90% likelihood of attaining a euploid embryo. Conclusions: This tool can serve as a counseling adjunct by providing individualized cost information for patients regarding PGT-A.
KW - Aneuploidy
KW - Cost analysis
KW - Counseling tool
KW - PGT
KW - Preimplantation genetic screening
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U2 - 10.1007/s10815-018-1275-5
DO - 10.1007/s10815-018-1275-5
M3 - Article
C2 - 30066304
AN - SCOPUS:85052106316
SN - 1058-0468
VL - 35
SP - 1641
EP - 1650
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 9
ER -