The Consequences of Aging on the Response to Injury and Critical Illness

Bellal Joseph, Thomas Scalea

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Changing demographic trends have led to an increase in the overall geriatric trauma patient volume. Furthermore, the intersection of aging and injury can be problematic because geriatric patients have multiple comorbidities, geriatric-specific syndromes, and reduced physiological reserve. Despite mounting evidence that frail geriatric patients have inferior outcomes following trauma, very few studies have examined the effect of aging on the biological response to injury. In the present article, we review the current literature and explore the pathophysiological rationale underlying observed data, available evidence, and future directions on this topic.

Original languageEnglish (US)
Pages (from-to)144-153
Number of pages10
Issue number2
StatePublished - Aug 1 2020


  • Aging
  • frailty
  • geriatric
  • inflammation
  • physiological reserve
  • senescence
  • trauma specific frailty index

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine


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