The complex role of prostaglandin E2-EP receptor signaling in wound healing

Kristy E. Gilman; Kirsten H. Limesand

doi:10.1152/AJPREGU.00185.2020

The complex role of prostaglandin E₂-EP receptor signaling in wound healing

Kristy E. Gilman, Kirsten H. Limesand

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E₂ (PGE₂) being the most complex and exhibiting the most diverse physiological outputs. PGE₂ signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE₂ and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.

Original language	English (US)
Pages (from-to)	R287-R296
Journal	American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume	320
Issue number	3
DOIs	https://doi.org/10.1152/AJPREGU.00185.2020
State	Published - Mar 2021

Keywords

Cell signaling
Prostaglandins
Repair
Tissue damage
Wound healing

ASJC Scopus subject areas

Physiology
Physiology (medical)

Access to Document

10.1152/AJPREGU.00185.2020

Cite this

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abstract = "Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E2 (PGE2) being the most complex and exhibiting the most diverse physiological outputs. PGE2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.",

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AB - Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E2 (PGE2) being the most complex and exhibiting the most diverse physiological outputs. PGE2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.

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