The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Kit S. Lam; Victor J. Hruby; Michal Lebl; Richard J. Knapp; Wieslaw M. Kazmierski; Evan M. Hersh; Sydney E. Salmon

doi:10.1016/S0960-894X(01)80224-9

The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Kit S. Lam, Victor J. Hruby, Michal Lebl, Richard J. Knapp, Wieslaw M. Kazmierski, Evan M. Hersh, Sydney E. Salmon

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

A method is outlined for preparing large, diverse peptide libraries (10⁵-10⁷ peptides) such that there is one peptide per bead. These libraries can be used to screen for binding to macromolecular receptor (acceptor) molecules and to determine the structure of the peptides that bind.

Original language	English (US)
Pages (from-to)	419-424
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(01)80224-9
State	Published - Mar 1993
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)80224-9

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abstract = "A method is outlined for preparing large, diverse peptide libraries (105-107 peptides) such that there is one peptide per bead. These libraries can be used to screen for binding to macromolecular receptor (acceptor) molecules and to determine the structure of the peptides that bind.",

author = "Lam, {Kit S.} and Hruby, {Victor J.} and Michal Lebl and Knapp, {Richard J.} and Kazmierski, {Wieslaw M.} and Hersh, {Evan M.} and Salmon, {Sydney E.}",

note = "Funding Information: part by the National Institutes of",

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AU - Hruby, Victor J.

AU - Lebl, Michal

AU - Knapp, Richard J.

AU - Kazmierski, Wieslaw M.

AU - Hersh, Evan M.

AU - Salmon, Sydney E.

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The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Abstract

ASJC Scopus subject areas

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