The Chemical Biology of NO that Regulates Oncogenic Signaling and Metabolism: NOS2 and Its Role in Inflammatory Disease

Katrina M. Miranda, Lisa A. Ridnour, Robert Y.S. Cheng, David A. Wink, Douglas D. Thomas

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Nitric oxide (NO) and the enzyme that synthesizes it, nitric oxide synthase 2 (NOS2), have emerged as key players in inflammation and cancer. Expression of NOS2 in tumors has been correlated both with positive outcomes and with poor prognoses. The chemistry of NO is the major determinate to the biological outcome and the concentration of NO, which can range over five orders of magnitude, is critical in determining which pathways are activated. It is the activation of specific oncogenic and immunological mechanisms that shape the outcome. The kinetics of specific reactions determine the mechanisms of action. In this review, the relevant reactions of NO and related species are discussed with respect to these oncogenic and immunological signals.

Original languageEnglish (US)
Pages (from-to)27-45
Number of pages19
JournalCritical reviews in oncogenesis
Volume28
Issue number1
DOIs
StatePublished - 2023

Keywords

  • cancer biology
  • cell signaling
  • nitric oxide
  • nitric oxide synthase

ASJC Scopus subject areas

  • Cancer Research

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