The cardiometabolic syndrome as a cardiovascular risk factor

Gurushankar Govindarajan, Adam Whaley-Connell, Maryann Mugo, Craig Stump, James R. Sowers

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


The cardiometabolic syndrome (CMS) is associated with cardiovascular disease (CVD) and includes a constellation of risk factors such as central obesity, hypertension, insulin resistance, dyslipidemia, microalbuminuria, and hypercoagulability. Collectively, these risk factors increase CVD endpoints such as stroke, congestive heart failure, chronic kidney disease (CKD), and overall mortality. The CMS is associated with endothelial dysfunction, inflammation, abnormal thrombolysis, and increased oxidative stress that accentuate progression of CVD. We will review how the varying components of the CMS relate to an increased CVD and renal disease risk.

Original languageEnglish (US)
Pages (from-to)311-318
Number of pages8
JournalAmerican Journal of the Medical Sciences
Issue number6
StatePublished - Dec 2005


  • Cardiometabolic syndrome
  • Endothelial dysfunction
  • Hypertension
  • Microalbuminuria
  • Obesity

ASJC Scopus subject areas

  • General Medicine


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