@article{ae642ed8d80441b5b8624eece6000130,
title = "The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention",
abstract = "The Breast Cancer Weight Loss (BWEL) trial is a randomized controlled trial designed to determine whether weight loss after a breast cancer diagnosis can reduce the risk of cancer recurrence in women with overweight or obesity. The BWEL trial will compare the efficacy of a telephone-based weight-loss intervention plus health education materials versus health education materials alone on invasive disease-free survival in 3,181 women with stage II or III breast cancer and BMI > 27 kg/m2. This report provides a detailed description of the goals and methods of the lifestyle intervention and the evidence supporting the intervention used in the BWEL trial. The intervention{\textquoteright}s primary goal for participants is to achieve and maintain a weight loss ≥ 10% of baseline weight through increased physical activity and caloric restriction. The evidence supporting the diet, physical activity, and behavioral components of this telephone-based weight-loss intervention, as well as strategies to promote participant engagement and retention, is described. The intervention is provided through 42 sessions delivered by trained health coaches over a 2-year period. If the BWEL lifestyle intervention is successful in improving cancer outcomes, then weight loss will be incorporated into the care of thousands of breast cancer patients.",
author = "Delahanty, {Linda M.} and Wadden, {Thomas A.} and Goodwin, {Pamela J.} and Alfano, {Catherine M.} and Thomson, {Cynthia A.} and Irwin, {Melinda L.} and Neuhouser, {Marian L.} and Crane, {Tracy E.} and Elizabeth Frank and Spears, {Patricia A.} and Gillis, {Bonnie P.} and Hershman, {Dawn L.} and Paskett, {Electra D.} and Judith Hopkins and Vanessa Bernstein and Vered Stearns and Julia White and Clifford Hudis and Winer, {Eric P.} and {A. Carey}, Lisa and Partridge, {Ann H.} and Ligibel, {Jennifer A.}",
note = "Funding Information: Research reported in this publication was supported by the National Cancer Institute (NCI) of the NIH under award numbers U10CA180821 and U10CA180882 (to the Alliance for Clinical Trials in Oncology; JAL, PAS, EDP, JH, and EPW), as well as UG1CA233180, UG1CA233184, UG1CA233196, UG1CA233290, UG1CA233331, UG1CA233337, UG1CA233373, U10CA180819, UG1CA189850, UG1CA189858, and UG1CA189823; U10CA180863 and Canadian Cancer Society Research Institute grant 703547 (Canadian Cancer Trials Group; VB and PJG); U10CA180820, UG1CA189828, and UG1CA233198 (Eastern Cooperative Oncology Group-American College of Radiology Imaging Network; VS); U10CA180868 (NRG Oncology Foundation, Inc.; JW); and UG1CA189974 and UG1CA233328 (Southwest Oncology Group; DLH and MLN). Additional support was provided to JAL by the Susan G. Komen Foundation, Breast Cancer Research Foundation, and the American Cancer Society. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH (https://acknowledgments.alliancefound.org) Funding Information: Research reported in this publication was supported by the National Cancer Institute (NCI) of the NIH under award numbers U10CA180821 and U10CA180882 (to the Alliance for Clinical Trials in Oncology; JAL, PAS, EDP, JH, and EPW), as well as UG1CA233180, UG1CA233184, UG1CA233196, UG1CA233290, UG1CA233331, UG1CA233337, UG1CA233373, U10CA180819, UG1CA189850, UG1CA189858, and UG1CA189823; U10CA180863 and Canadian Cancer Society Research Institute grant 703547 (Canadian Cancer Trials Group; VB and PJG); U10CA180820, UG1CA189828, and UG1CA233198 (Eastern Cooperative Oncology Group‐American College of Radiology Imaging Network; VS); U10CA180868 (NRG Oncology Foundation, Inc.; JW); and UG1CA189974 and UG1CA233328 (Southwest Oncology Group; DLH and MLN). Additional support was provided to JAL by the Susan G. Komen Foundation, Breast Cancer Research Foundation, and the American Cancer Society. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH ( https://acknowledgments.alliancefound.org ) Publisher Copyright: {\textcopyright} 2021 The Obesity Society (TOS)",
year = "2022",
month = jan,
doi = "10.1002/oby.23287",
language = "English (US)",
volume = "30",
pages = "28--38",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "1",
}