The Bowman-Birk inhibitor-polyester conjugate: Synthesis, inhibition of serine proteinases, and suppression of radiation transformation in vitro

N. I. Larionova; I. N. Topchieva; I. P. Gladysheva; A. R. Kennedy

The Bowman-Birk inhibitor-polyester conjugate: Synthesis, inhibition of serine proteinases, and suppression of radiation transformation in vitro

N. I. Larionova, I. N. Topchieva, I. P. Gladysheva, A. R. Kennedy

Research output: Contribution to journal › Article › peer-review

Abstract

The Bowman-Birk soybean inhibitor (BBI) was modified by the monoaldehyde derivative of block copolymer of ethylene oxide and propylene oxide, Mr 2000. This copolymer is capable of pentrating through biological membranes. The conjugate contained five covalently bound polymer chains per protein molecule. The modified BBI retained the capacity for effective inhibition of α-chymotrypsin (K(i) = 4.0 x 10^-8 M) and human leukocyte elastase (K(i) = 1.2 x 10^-7 M). BBI-conjugate, like purified BBI, suppressed radiation transformation in vitro.

Original language	English (US)
Pages (from-to)	158-163
Number of pages	6
Journal	Cancer Journal
Volume	7
Issue number	4
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "The Bowman-Birk inhibitor-polyester conjugate: Synthesis, inhibition of serine proteinases, and suppression of radiation transformation in vitro",

abstract = "The Bowman-Birk soybean inhibitor (BBI) was modified by the monoaldehyde derivative of block copolymer of ethylene oxide and propylene oxide, Mr 2000. This copolymer is capable of pentrating through biological membranes. The conjugate contained five covalently bound polymer chains per protein molecule. The modified BBI retained the capacity for effective inhibition of α-chymotrypsin (K(i) = 4.0 x 10-8 M) and human leukocyte elastase (K(i) = 1.2 x 10-7 M). BBI-conjugate, like purified BBI, suppressed radiation transformation in vitro.",

author = "Larionova, {N. I.} and Topchieva, {I. N.} and Gladysheva, {I. P.} and Kennedy, {A. R.}",

year = "1994",

language = "English (US)",

volume = "7",

pages = "158--163",

journal = "Cancer Journal",

issn = "0765-7846",

publisher = "Lippincott Williams and Wilkins",

number = "4",

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T1 - The Bowman-Birk inhibitor-polyester conjugate

T2 - Synthesis, inhibition of serine proteinases, and suppression of radiation transformation in vitro

AU - Larionova, N. I.

AU - Topchieva, I. N.

AU - Gladysheva, I. P.

AU - Kennedy, A. R.

PY - 1994

Y1 - 1994

N2 - The Bowman-Birk soybean inhibitor (BBI) was modified by the monoaldehyde derivative of block copolymer of ethylene oxide and propylene oxide, Mr 2000. This copolymer is capable of pentrating through biological membranes. The conjugate contained five covalently bound polymer chains per protein molecule. The modified BBI retained the capacity for effective inhibition of α-chymotrypsin (K(i) = 4.0 x 10-8 M) and human leukocyte elastase (K(i) = 1.2 x 10-7 M). BBI-conjugate, like purified BBI, suppressed radiation transformation in vitro.

AB - The Bowman-Birk soybean inhibitor (BBI) was modified by the monoaldehyde derivative of block copolymer of ethylene oxide and propylene oxide, Mr 2000. This copolymer is capable of pentrating through biological membranes. The conjugate contained five covalently bound polymer chains per protein molecule. The modified BBI retained the capacity for effective inhibition of α-chymotrypsin (K(i) = 4.0 x 10-8 M) and human leukocyte elastase (K(i) = 1.2 x 10-7 M). BBI-conjugate, like purified BBI, suppressed radiation transformation in vitro.

UR - http://www.scopus.com/inward/record.url?scp=0028129673&partnerID=8YFLogxK

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M3 - Article

AN - SCOPUS:0028129673

SN - 0765-7846

VL - 7

SP - 158

EP - 163

JO - Cancer Journal

JF - Cancer Journal

IS - 4

ER -

The Bowman-Birk inhibitor-polyester conjugate: Synthesis, inhibition of serine proteinases, and suppression of radiation transformation in vitro

Abstract

ASJC Scopus subject areas

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