The biology of schlemm’s canal

Research output: Chapter in Book/Report/Conference proceedingChapter


As aqueous humor drains, it is collected by a venous vessel, Schlemm’s canal, which encircles the eye at the corneoscleral junction. Apart from its role in returning aqueous humor to the systemic circulation, Schlemm’s canal participates in the generation of resistance to its drainage that serves to maintain intraocular pressure at a relatively constant level over a lifetime. Such regulation is accomplished by unique anatomical and physiological features of the inner wall and its relationship with the underlying trabecular meshwork cells and extracellular matrix in the juxtacanalicular tissue region of the conventional drainage pathway. Dysfunction of this region results in ocular hypertension, the primary risk factor for a group of diseases known as glaucoma.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Eye, Four-Volume Set
Number of pages8
ISBN (Electronic)9780123742032
ISBN (Print)9780123741981
StatePublished - Jan 1 2010


  • Aqueous humor
  • Collector channel
  • Endothelia
  • Giant vacuole
  • Glaucoma
  • Intraocular pressure
  • Juxtacanalicular
  • Outflow facility
  • Pore
  • Trabecular meshwork
  • Vascular
  • Venous

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'The biology of schlemm’s canal'. Together they form a unique fingerprint.

Cite this