TY - JOUR
T1 - The association of osteoarthritis risk factors with localized, regional and diffuse knee pain
AU - Thompson, L. R.
AU - Boudreau, R.
AU - Newman, A. B.
AU - Hannon, M. J.
AU - Chu, C. R.
AU - Nevitt, M. C.
AU - Kent Kwoh, C.
N1 - Funding Information:
The OAI is a public–private partnership which comprised five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health , a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories ; Novartis Pharmaceuticals Corporation , GlaxoSmithKline ; and Pfizer, Inc . Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health . This manuscript has received the approval of the OAI Publications Committee based on a review of its scientific content and data interpretation.
Funding Information:
This study was also supported by the National Institute of Aging (NIA) Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant AG 021885 , and the University of Pittsburgh, School of Medicine Clinical Scientist Training Program .
PY - 2010/10
Y1 - 2010/10
N2 - Objective: To identify determinants of different patterns of knee pain with a focus on risk factors for knee osteoarthritis (OA). Design: The Knee Pain Map is an interviewer-administered assessment that asks subjects to characterize their knee pain as localized, regional, or diffuse. A total of 2677 participants from the Osteoarthritis Initiative were studied.We used multinomial logistic regression to examine the relationship between risk factors for OA and knee pain patterns. We examined the bivariate and multivariate relationships of knee pain pattern with age, body mass index (BMI), sex, race, family history of total joint replacement, knee injury, knee surgery, and hand OA. Results: We compared 2462 knees with pain to 1805 knees without pain. In the bivariate analysis, age, sex, BMI, injury, surgery, and hand OA were associated with at least one pain pattern. In the multivariate model, all of these variables remained significantly associated with at least one pattern. When compared to knees without pain, higher BMI, injury, and surgery were associated with all patterns. BMI had its strongest association with diffuse pain. Older age was less likely to be associated with localized pain while female sex was associated with regional pain. Conclusions: We have shown that specific OA risk factors are associated with different knee pain patterns. Better understanding of the relationship between OA risk factors and knee pain patterns may help to characterize the heterogeneous subsets of knee OA.
AB - Objective: To identify determinants of different patterns of knee pain with a focus on risk factors for knee osteoarthritis (OA). Design: The Knee Pain Map is an interviewer-administered assessment that asks subjects to characterize their knee pain as localized, regional, or diffuse. A total of 2677 participants from the Osteoarthritis Initiative were studied.We used multinomial logistic regression to examine the relationship between risk factors for OA and knee pain patterns. We examined the bivariate and multivariate relationships of knee pain pattern with age, body mass index (BMI), sex, race, family history of total joint replacement, knee injury, knee surgery, and hand OA. Results: We compared 2462 knees with pain to 1805 knees without pain. In the bivariate analysis, age, sex, BMI, injury, surgery, and hand OA were associated with at least one pain pattern. In the multivariate model, all of these variables remained significantly associated with at least one pattern. When compared to knees without pain, higher BMI, injury, and surgery were associated with all patterns. BMI had its strongest association with diffuse pain. Older age was less likely to be associated with localized pain while female sex was associated with regional pain. Conclusions: We have shown that specific OA risk factors are associated with different knee pain patterns. Better understanding of the relationship between OA risk factors and knee pain patterns may help to characterize the heterogeneous subsets of knee OA.
KW - Knee osteoarthritis
KW - Knee pain
KW - Pain localization
KW - Risk factors
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U2 - 10.1016/j.joca.2010.05.014
DO - 10.1016/j.joca.2010.05.014
M3 - Article
C2 - 20633678
AN - SCOPUS:77956871632
SN - 1063-4584
VL - 18
SP - 1244
EP - 1249
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 10
ER -