Abstract
Bone regeneration is a complicated process that involves a series of biological events, such as cellular recruitment, proliferation and differentiation, and so forth, which have been found to be significantly affected by controlled drug delivery. Recently, a lot of research studies have been launched on the application of nanomaterials in controlled drug delivery for bone regeneration. In this article, the latest research progress in this area regarding the use of bioceramics-based, polymer-based, metallic oxide-based and other types of nanomaterials in controlled drug delivery for bone regeneration are reviewed and discussed, which indicates that the controlling drug delivery with nanomaterials should be a very promising treatment in orthopedics. Furthermore, some new challenges about the future research on the application of nanomaterials in controlled drug delivery for bone regeneration are described in the conclusion and perspectives part.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3978-3992 |
| Number of pages | 15 |
| Journal | Journal of Biomedical Materials Research - Part A |
| Volume | 103 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2015 |
Keywords
- bone regeneration
- controlled drug delivery
- nanomaterials
ASJC Scopus subject areas
- Ceramics and Composites
- Biomaterials
- Biomedical Engineering
- Metals and Alloys